Intraprostatic inflammation is positively associated with serum PSA in men with PSA <4 ng ml(-1), normal DRE and negative for prostate cancer

Intraprostatic inflammation is positively associated with serum PSA in men with PSA <4 ng ml(-1), normal DRE and negative for prostate cancer

Biopsies performed for elevated serum PSA often show inflammatory infiltrates. However, the influence of intraprostatic inflammation on serum PSA in men without biopsy indication and negative for prostate cancer has not been described in detail. We studied 224 men in the placebo arm of the Prostate...

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Veröffentlicht in:Prostate cancer and prostatic diseases 2015-09, Vol.18 (3), p.264-269
Hauptverfasser: Umbehr, M H, Gurel, B, Murtola, T J, Sutcliffe, S, Peskoe, S B, Tangen, C M, Goodman, P J, Thompson, I M, Lippman, S M, Lucia, M S, Parnes, H L, Drake, C G, Nelson, W G, De Marzo, A M, Platz, E A
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Aged, 80 and over
Biopsy
Case-Control Studies
Cross-Sectional Studies
Humans
Inflammation - pathology
Male
Middle Aged
Prostate - pathology
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - pathology
Risk Factors
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Zusammenfassung:Biopsies performed for elevated serum PSA often show inflammatory infiltrates. However, the influence of intraprostatic inflammation on serum PSA in men without biopsy indication and negative for prostate cancer has not been described in detail. We studied 224 men in the placebo arm of the Prostate Cancer Prevention Trial (PCPT) who underwent end-of-study biopsy per trial protocol, had PSA 0 to ≤0.8, >0.8 to ≤1.5 and >1.5 to
ISSN:1365-7852
1476-5608
DOI:10.1038/pcan.2015.19