PTEN loss and ERG protein expression are infrequent in prostatic ductal adenocarcinomas and concurrent acinar carcinomas

BACKGROUND Prostatic ductal adenocarcinoma is an unusual and aggressive morphologic subtype of prostate cancer. PTEN gene deletion and ERG gene rearrangement are among the most common genomic changes in acinar prostate cancers. Though ductal adenocarcinoma most commonly occurs with synchronous usual...

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Veröffentlicht in:	The Prostate 2015-10, Vol.75 (14), p.1610-1619
Hauptverfasser:	Morais, Carlos L., Herawi, Mehsati, Toubaji, Antoun, Albadine, Roula, Hicks, Jessica, Netto, George J., De Marzo, Angelo M., Epstein, Jonathan I., Lotan, Tamara L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers, Tumor - biosynthesis Carcinoma, Acinar Cell - metabolism Carcinoma, Acinar Cell - pathology Carcinoma, Ductal - metabolism Carcinoma, Ductal - pathology ductal adenocarcinoma endometrioid ERG Gene Expression Regulation, Neoplastic Humans immunohistochemistry Male prostatic adenocarcinoma Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology PTEN PTEN Phosphohydrolase - deficiency Trans-Activators - biosynthesis Transcriptional Regulator ERG
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