UPRT, a suicide-gene therapy candidate in higher eukaryotes, is required for Drosophila larval growth and normal adult lifespan

Uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage pathway enzyme that catalyzes the conversion of uracil to uridine monophosphate (UMP). The enzyme is highly conserved from prokaryotes to humans and yet phylogenetic evidence suggests that UPRT homologues from higher-eukaryotes, includi...

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Veröffentlicht in:	Scientific reports 2015-08, Vol.5 (1), p.13176-13176, Article 13176
Hauptverfasser:	Ghosh, Arpan C., Shimell, MaryJane, Leof, Emma R., Haley, Macy J., O’Connor, Michael B.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/136/334/1582/715 Aging - physiology Animals BASIC BIOLOGICAL SCIENCES Drosophila melanogaster - growth & development Drosophila melanogaster - metabolism Drosophila Proteins - physiology Drug development Enzymatic activity Enzymes Gene Expression Regulation, Developmental - physiology Gene therapy Humanities and Social Sciences Insects Larva - growth & development Larva - metabolism Larval development Life span Longevity - physiology mRNA multidisciplinary Pentosyltransferases - physiology Phosphoribosyltransferase Phylogeny Prokaryotes Science Science & Technology - Other Topics Suicide Suicide genes Therapeutic applications Uracil Uracil phosphoribosyltransferase Uridine Uridine monophosphate
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