Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis

Breakdown of the major sleep-promoting neurotransmitter, γ-aminobutyric acid (GABA), in the GABA shunt generates catabolites that may enter the tricarboxylic acid cycle, but it is unknown whether catabolic by-products of the GABA shunt actually support metabolic homeostasis. In Drosophila, the loss...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of biological chemistry 2015-08, Vol.290 (33), p.20407-20416
Hauptverfasser:	Maguire, Sarah E., Rhoades, Seth, Chen, Wen-Feng, Sengupta, Arjun, Yue, Zhifeng, Lim, Jason C., Mitchell, Claire H., Weljie, Aalim M., Sehgal, Amita
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminobutyrate Transaminase - genetics 4-Aminobutyrate Transaminase - metabolism amino acid Animals Brain - enzymology Brain - metabolism Brain - physiology Drosophila melanogaster Drosophila metabolism Energy Metabolism glutamate Glutamic Acid - metabolism Homeostasis Ketoglutaric Acids - metabolism Metabolism mitochondria Mutation Oxidative Stress Sleep tricarboxylic acid cycle (TCA cycle) (Krebs cycle)
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!