Physiological Consequences of Compartmentalized Acyl-CoA Metabolism
Meeting the complex physiological demands of mammalian life requires strict control of the metabolism of long-chain fatty acyl-CoAs because of the multiplicity of their cellular functions. Acyl-CoAs are substrates for energy production; stored within lipid droplets as triacylglycerol, cholesterol es...
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| Veröffentlicht in: | The Journal of biological chemistry 2015-08, Vol.290 (33), p.20023-20031 |
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| container_issue | 33 |
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| container_title | The Journal of biological chemistry |
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| creator | Cooper, Daniel E. Young, Pamela A. Klett, Eric L. Coleman, Rosalind A. |
| description | Meeting the complex physiological demands of mammalian life requires strict control of the metabolism of long-chain fatty acyl-CoAs because of the multiplicity of their cellular functions. Acyl-CoAs are substrates for energy production; stored within lipid droplets as triacylglycerol, cholesterol esters, and retinol esters; esterified to form membrane phospholipids; or used to activate transcriptional and signaling pathways. Indirect evidence suggests that acyl-CoAs do not wander freely within cells, but instead, are channeled into specific pathways. In this review, we will discuss the evidence for acyl-CoA compartmentalization, highlight the key modes of acyl-CoA regulation, and diagram potential mechanisms for controlling acyl-CoA partitioning. |
| doi_str_mv | 10.1074/jbc.R115.663260 |
| format | Article |
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Acyl-CoAs are substrates for energy production; stored within lipid droplets as triacylglycerol, cholesterol esters, and retinol esters; esterified to form membrane phospholipids; or used to activate transcriptional and signaling pathways. Indirect evidence suggests that acyl-CoAs do not wander freely within cells, but instead, are channeled into specific pathways. 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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Acyl Coenzyme A - metabolism acyl-CoA Acylation acyltransferase Animals Cell Compartmentation Culture Media fatty acid metabolism fatty acid oxidation Homeostasis Mice Mice, Knockout Minireviews phospholipid Signal Transduction Substrate Specificity Thermogenesis thioesterase triacylglycerol |
| title | Physiological Consequences of Compartmentalized Acyl-CoA Metabolism |
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