IL-18 acts in synergy with IL-7 to promote ex vivo expansion of T lymphoid progenitor cells

Although IL-18 has not previously been shown to promote T lymphopoiesis, results obtained via a novel data mining algorithm (global microarray meta-analysis) led us to explore a predicted role for this cytokine in T cell development. IL-18 is a member of the IL-1 cytokine family that has been extens...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-04, Vol.194 (8), p.3820-3828
Hauptverfasser:	Gandhapudi, Siva K, Tan, Chibing, Marino, Julie H, Taylor, Ashlee A, Pack, Christopher C, Gaikwad, Joel, Van De Wiele, C Justin, Wren, Jonathan D, Teague, T Kent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - physiology Cell Proliferation - physiology Cells, Cultured Gene Expression Profiling Gene Expression Regulation - immunology Interleukin-18 - agonists Interleukin-18 - genetics Interleukin-18 - immunology Interleukin-7 - agonists Interleukin-7 - genetics Interleukin-7 - immunology Lymphopoiesis - genetics Lymphopoiesis - immunology Mice Mice, Mutant Strains Oligonucleotide Array Sequence Analysis Precursor Cells, T-Lymphoid - cytology Precursor Cells, T-Lymphoid - immunology Proto-Oncogene Proteins c-kit - genetics Proto-Oncogene Proteins c-kit - immunology Signal Transduction - genetics Signal Transduction - immunology
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