Retention of duplicated ITAM-containing transmembrane signaling subunits in the tetraploid amphibian species Xenopus laevis

The ITAM-bearing transmembrane signaling subunits (TSS) are indispensable components of activating leukocyte receptor complexes. The TSS-encoding genes map to paralogous chromosomal regions, which are thought to arise from ancient genome tetraploidization(s). To assess a possible role of tetraploidi...

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Veröffentlicht in:	Developmental and comparative immunology 2015-11, Vol.53 (1), p.158-168
Hauptverfasser:	Guselnikov, S.V., Grayfer, L., De Jesús Andino, F., Rogozin, I.B., Robert, J., Taranin, A.V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating receptor complexes Amino Acid Sequence Animals Base Sequence Cell Line Evolution, Molecular Genome mining HEK293 Cells Humans Immunogenetics Immunoreceptor Tyrosine-Based Activation Motif - genetics Molecular Sequence Data Protein dosage effect Receptors, Antigen, T-Cell, alpha-beta - genetics Receptors, Antigen, T-Cell, alpha-beta - immunology Receptors, IgG - genetics Receptors, IgG - immunology Sequence Alignment Signal Transduction - genetics Signal Transduction - immunology TCR Tetraploidization Tetraploidy Xenopus Xenopus laevis
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