HTR7 Mediates Serotonergic Acute and Chronic Itch

Chronic itch is a prevalent and debilitating condition for which few effective therapies are available. We harnessed the natural variation across genetically distinct mouse strains to identify transcripts co-regulated with itch behavior. This survey led to the discovery of the serotonin receptor HTR...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2015-07, Vol.87 (1), p.124-138
Hauptverfasser:	Morita, Takeshi, McClain, Shannan P., Batia, Lyn M., Pellegrino, Maurizio, Wilson, Sarah R., Kienzler, Michael A., Lyman, Kyle, Olsen, Anne Sofie Braun, Wong, Justin F., Stucky, Cheryl L., Brem, Rachel B., Bautista, Diana M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Animals Behavior Cell culture Chronic Disease Dermatitis Dermatitis, Atopic - genetics Dermatitis, Atopic - metabolism Disease Models, Animal Experiments Ganglia, Spinal - metabolism Gene expression Gene Expression Profiling Genomics Histology Humans Laboratories Mice Mice, Inbred C57BL - genetics Mice, Inbred C57BL - metabolism Mice, Inbred DBA - genetics Mice, Inbred DBA - metabolism Neurons Neurosciences Pain Pruritus - chemically induced Pruritus - genetics Pruritus - metabolism Receptors, Serotonin - drug effects Receptors, Serotonin - genetics Receptors, Serotonin - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Rodents Serotonin - pharmacology Serotonin Receptor Agonists - pharmacology Serotonin Uptake Inhibitors - adverse effects Serotonin Uptake Inhibitors - pharmacology Studies Transient Receptor Potential Channels - drug effects Transient Receptor Potential Channels - genetics Transient Receptor Potential Channels - metabolism TRPA1 Cation Channel
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