An ADP-Ribosyltransferase as a Potential Target for Nitric Oxide Action in Hippocampal Long-Term Potentiation

Recent studies of long-term potentiation (LTP) in the CA1 region of the hippocampus have demonstrated that nitric oxide (NO) may be involved in some forms of LTP and have suggested that postsynaptically generated NO is a candidate to act as a retrograde messenger. However, the molecular target(s) of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1994-12, Vol.91 (25), p.11958-11962
Hauptverfasser:	Schuman, Erin M., Meffert, Mollie K., Schulman, Howard, Madison, Daniel V.
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Amino-5-phosphonovalerate - pharmacology Amino acids Animals Benzamides Biology Brain Cyclic GMP - physiology Dibutyryl Cyclic GMP - pharmacology Electrodes Evoked Potentials - drug effects Evoked Potentials - physiology Hippocampus Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Inhibitory concentration 50 Long term potentiation Long-Term Potentiation - drug effects Long-Term Potentiation - physiology Male Molsidomine - analogs & derivatives Molsidomine - pharmacology N-Methylaspartate - pharmacology NAD - metabolism Neurology Neurons Niacinamide - pharmacology Nitric Oxide - physiology Oxides Poly(ADP-ribose) Polymerase Inhibitors Poly(ADP-ribose) Polymerases - metabolism Pyramidal Cells - drug effects Pyramidal Cells - enzymology Pyramidal Cells - physiology Rats Rats, Sprague-Dawley Synaptic transmission Tetanus Vasodilator Agents - pharmacology
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