Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

Translation initiation in eukaryotes begins with the formation of a pre-initiation complex (PIC) containing the 40S ribosomal subunit, eIF1, eIF1A, eIF3, ternary complex (eIF2-GTP-Met-tRNAi), and eIF5. The PIC, in an open conformation, attaches to the 5′ end of the mRNA and scans to locate the start...

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Veröffentlicht in:	Molecular cell 2015-08, Vol.59 (3), p.399-412
Hauptverfasser:	Llácer, Jose L., Hussain, Tanweer, Marler, Laura, Aitken, Colin Echeverría, Thakur, Anil, Lorsch, Jon R., Hinnebusch, Alan G., Ramakrishnan, V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Cryoelectron Microscopy Eukaryotic Initiation Factors - chemistry Eukaryotic Initiation Factors - metabolism Kluyveromyces - chemistry Kluyveromyces - metabolism Models, Molecular Peptide Chain Initiation, Translational Protein Binding Protein Conformation Protein Multimerization Ribosome Subunits, Small, Eukaryotic - chemistry Ribosome Subunits, Small, Eukaryotic - metabolism RNA, Fungal - metabolism RNA, Messenger - metabolism RNA, Transfer - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - metabolism
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