Capsular Polysaccharide Is Involved in NLRP3 Inflammasome Activation by Klebsiella pneumoniae Serotype K1

Klebsiella pneumoniae (strain 43816, K2 serotype) induces interleukin-1β (IL-1β) secretion, but neither the bacterial factor triggering the activation of these inflammasome-dependent responses nor whether they are mediated by NLRP3 or NLRC4 is known. In this study, we identified a capsular polysacch...

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Veröffentlicht in:	Infection and immunity 2015-09, Vol.83 (9), p.3396-3409
Hauptverfasser:	Hua, Kuo-Feng, Yang, Feng-Ling, Chiu, Hsiao-Wen, Chou, Ju-Ching, Dong, Wei-Chih, Lin, Chien-Nan, Lin, Chai-Yi, Wang, Jin-Town, Li, Lan-Hui, Chiu, Huan-Wen, Chiu, Yi-Chich, Wu, Shih-Hsiung
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Bacterial - immunology Blotting, Western Carrier Proteins - immunology Cell Line Enzyme-Linked Immunosorbent Assay Host Response and Inflammation Host-Parasite Interactions - immunology Humans Inflammasomes - immunology Interleukin-1beta - immunology Klebsiella Infections - immunology Klebsiella pneumoniae - immunology Mice NLR Family, Pyrin Domain-Containing 3 Protein Polysaccharides, Bacterial - immunology Real-Time Polymerase Chain Reaction
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