Catalytic asymmetric hydroamination of unactivated internal olefins to aliphatic amines

Catalytic assembly of enantiopure aliphatic amines from abundant and readily available precursors has long been recognized as a paramount challenge in synthetic chemistry. Here, we describe a mild and general copper-catalyzed hydroamination that effectively converts unactivated internal olefins—an i...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2015-07, Vol.349 (6243), p.62-66
Hauptverfasser:	Yang, Yang, Shi, Shi-Liang, Niu, Dawen, Liu, Peng, Buchwald, Stephen L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aliphatic amines Aliphatic compounds Amines Catalysis Catalysts Chemical bonds Chemical compounds Chemical synthesis Commodities Olefins Organic Chemistry Pharmaceuticals
Online-Zugang:	Volltext
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