HLA-DR antigen expression on the thyrocytes of Graves' disease patients
To confirm the expression of HLA-DR antigen on the thyrocytes of Graves’ disease patients and study the relation between the degree of DR antigen expression and clinical or laboratory indices, double immunofluorescence and immunoenzymatic staining were performed on frozen thyroid sections. DR antige...
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| Veröffentlicht in: | The Korean journal of internal medicine 1988-01, Vol.3 (1), p.15-24 |
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| container_title | The Korean journal of internal medicine |
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| creator | Lee, M S Shong, Y K Cho, B Y Lee, H K Koh, C S Min, H K Lee, M Oh, S K Whang, E S Cha, C Y |
| description | To confirm the expression of HLA-DR antigen on the thyrocytes of Graves’ disease patients and study the relation between the degree of DR antigen expression and clinical or laboratory indices, double immunofluorescence and immunoenzymatic staining were performed on frozen thyroid sections. DR antigen was expressed on the thyrocytes of 8 of 11 patients with Graves’ disease (73%) but not found on the thyrocytes from 6 normal controls. The degree of DR antigen expression had no apparent correlation with the age, duration of the disease, activity of TBII, titers of antimicrosomal and antithyroglobulin antibody. There was no apparent spatial or quantitative relation between lymphoid follicle formation and the DR antigen expression on the thyroid follicles. But DR antigen tended to be expressed on the thyroid tissue with interstitial, lymphocyte infiltration. In conclusion, DR antigen was expressed on the thyrocytes of Graves’ disease patients but the clinical and immunological significance remains to be clarified. |
| doi_str_mv | 10.3904/kjim.1988.3.1.15 |
| format | Article |
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DR antigen was expressed on the thyrocytes of 8 of 11 patients with Graves’ disease (73%) but not found on the thyrocytes from 6 normal controls. The degree of DR antigen expression had no apparent correlation with the age, duration of the disease, activity of TBII, titers of antimicrosomal and antithyroglobulin antibody. There was no apparent spatial or quantitative relation between lymphoid follicle formation and the DR antigen expression on the thyroid follicles. But DR antigen tended to be expressed on the thyroid tissue with interstitial, lymphocyte infiltration. In conclusion, DR antigen was expressed on the thyrocytes of Graves’ disease patients but the clinical and immunological significance remains to be clarified.</description><identifier>ISSN: 1226-3303</identifier><identifier>EISSN: 2005-6648</identifier><identifier>DOI: 10.3904/kjim.1988.3.1.15</identifier><identifier>PMID: 3153790</identifier><language>eng</language><publisher>Korea (South): Korean Association of Internal Medicine</publisher><subject>Adolescent ; Adult ; Female ; Graves Disease - immunology ; Graves Disease - pathology ; HLA-DR Antigens - analysis ; Humans ; Male ; Original ; T-Lymphocytes - immunology ; Thyroid Gland - immunology ; Thyroid Gland - pathology</subject><ispartof>The Korean journal of internal medicine, 1988-01, Vol.3 (1), p.15-24</ispartof><rights>Copyright © 1988 The Korean Association of Internal Medicine 1988</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1915-733f0f447e1ccdb9414c43b3291dcc982c8a2fc6c8272abf1fc6c3101ebac1563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532135/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4532135/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3153790$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, M S</creatorcontrib><creatorcontrib>Shong, Y K</creatorcontrib><creatorcontrib>Cho, B Y</creatorcontrib><creatorcontrib>Lee, H K</creatorcontrib><creatorcontrib>Koh, C S</creatorcontrib><creatorcontrib>Min, H K</creatorcontrib><creatorcontrib>Lee, M</creatorcontrib><creatorcontrib>Oh, S K</creatorcontrib><creatorcontrib>Whang, E S</creatorcontrib><creatorcontrib>Cha, C Y</creatorcontrib><title>HLA-DR antigen expression on the thyrocytes of Graves' disease patients</title><title>The Korean journal of internal medicine</title><addtitle>Korean J Intern Med</addtitle><description>To confirm the expression of HLA-DR antigen on the thyrocytes of Graves’ disease patients and study the relation between the degree of DR antigen expression and clinical or laboratory indices, double immunofluorescence and immunoenzymatic staining were performed on frozen thyroid sections. DR antigen was expressed on the thyrocytes of 8 of 11 patients with Graves’ disease (73%) but not found on the thyrocytes from 6 normal controls. The degree of DR antigen expression had no apparent correlation with the age, duration of the disease, activity of TBII, titers of antimicrosomal and antithyroglobulin antibody. There was no apparent spatial or quantitative relation between lymphoid follicle formation and the DR antigen expression on the thyroid follicles. But DR antigen tended to be expressed on the thyroid tissue with interstitial, lymphocyte infiltration. In conclusion, DR antigen was expressed on the thyrocytes of Graves’ disease patients but the clinical and immunological significance remains to be clarified.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Female</subject><subject>Graves Disease - immunology</subject><subject>Graves Disease - pathology</subject><subject>HLA-DR Antigens - analysis</subject><subject>Humans</subject><subject>Male</subject><subject>Original</subject><subject>T-Lymphocytes - immunology</subject><subject>Thyroid Gland - immunology</subject><subject>Thyroid Gland - pathology</subject><issn>1226-3303</issn><issn>2005-6648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRav24exFy0lPizk4-NhehVG2FgiB6XjbbSbu1TepuWuy_N6GlKMwwAzPzvMPL2A3wCHMeP3wt7CqCXMoII4ggOWF9wXkSpmksT1kfhEhDRI7n7ML7BedpxiX2WA8hwSznfTYaTwbh03ugq8bOqAroZ-3Ie1tXQRvNnNrcudrsGvJBXQYjp7fk74Op9aQ9BWvdWKoaf8XOSr30dH2ol-zz5fljOA4nb6PX4WASGsghCTPEkpdxnBEYMy3yGGITY4Eih6kxuRRGalGa1EiRCV2U0PUIHKjQBpIUL9njnrveFCuamlbb6aVaO7vSbqdqbdX_SWXnalZvVZygAExawN0B4OrvDflGraw3tFzqiuqNV5mUkGZp3i7y_aJxtfeOyqMIcNWZrzrzVWe-QgUKOvbt3-eOBwe38Rd3xYIW</recordid><startdate>19880101</startdate><enddate>19880101</enddate><creator>Lee, M S</creator><creator>Shong, Y K</creator><creator>Cho, B Y</creator><creator>Lee, H K</creator><creator>Koh, C S</creator><creator>Min, H K</creator><creator>Lee, M</creator><creator>Oh, S K</creator><creator>Whang, E S</creator><creator>Cha, C Y</creator><general>Korean Association of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19880101</creationdate><title>HLA-DR antigen expression on the thyrocytes of Graves' disease patients</title><author>Lee, M S ; Shong, Y K ; Cho, B Y ; Lee, H K ; Koh, C S ; Min, H K ; Lee, M ; Oh, S K ; Whang, E S ; Cha, C Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1915-733f0f447e1ccdb9414c43b3291dcc982c8a2fc6c8272abf1fc6c3101ebac1563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Female</topic><topic>Graves Disease - immunology</topic><topic>Graves Disease - pathology</topic><topic>HLA-DR Antigens - analysis</topic><topic>Humans</topic><topic>Male</topic><topic>Original</topic><topic>T-Lymphocytes - immunology</topic><topic>Thyroid Gland - immunology</topic><topic>Thyroid Gland - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, M S</creatorcontrib><creatorcontrib>Shong, Y K</creatorcontrib><creatorcontrib>Cho, B Y</creatorcontrib><creatorcontrib>Lee, H K</creatorcontrib><creatorcontrib>Koh, C S</creatorcontrib><creatorcontrib>Min, H K</creatorcontrib><creatorcontrib>Lee, M</creatorcontrib><creatorcontrib>Oh, S K</creatorcontrib><creatorcontrib>Whang, E S</creatorcontrib><creatorcontrib>Cha, C Y</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Korean journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, M S</au><au>Shong, Y K</au><au>Cho, B Y</au><au>Lee, H K</au><au>Koh, C S</au><au>Min, H K</au><au>Lee, M</au><au>Oh, S K</au><au>Whang, E S</au><au>Cha, C Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HLA-DR antigen expression on the thyrocytes of Graves' disease patients</atitle><jtitle>The Korean journal of internal medicine</jtitle><addtitle>Korean J Intern Med</addtitle><date>1988-01-01</date><risdate>1988</risdate><volume>3</volume><issue>1</issue><spage>15</spage><epage>24</epage><pages>15-24</pages><issn>1226-3303</issn><eissn>2005-6648</eissn><abstract>To confirm the expression of HLA-DR antigen on the thyrocytes of Graves’ disease patients and study the relation between the degree of DR antigen expression and clinical or laboratory indices, double immunofluorescence and immunoenzymatic staining were performed on frozen thyroid sections. DR antigen was expressed on the thyrocytes of 8 of 11 patients with Graves’ disease (73%) but not found on the thyrocytes from 6 normal controls. The degree of DR antigen expression had no apparent correlation with the age, duration of the disease, activity of TBII, titers of antimicrosomal and antithyroglobulin antibody. There was no apparent spatial or quantitative relation between lymphoid follicle formation and the DR antigen expression on the thyroid follicles. But DR antigen tended to be expressed on the thyroid tissue with interstitial, lymphocyte infiltration. In conclusion, DR antigen was expressed on the thyrocytes of Graves’ disease patients but the clinical and immunological significance remains to be clarified.</abstract><cop>Korea (South)</cop><pub>Korean Association of Internal Medicine</pub><pmid>3153790</pmid><doi>10.3904/kjim.1988.3.1.15</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Adult Female Graves Disease - immunology Graves Disease - pathology HLA-DR Antigens - analysis Humans Male Original T-Lymphocytes - immunology Thyroid Gland - immunology Thyroid Gland - pathology |
| title | HLA-DR antigen expression on the thyrocytes of Graves' disease patients |
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