Protective effects of metformin on reproductive function in obese male rats induced by high-fat diet

Purpose The study aims to elucidate the changes in testicular spermatogenic function in high-fat diet (HFD)-induced obese rats and to evaluate the protective effects of metformin intervention. Methods Male Sprague–Dawley rats ( n = 18) were randomly divided into a control group (standard diet), an...

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Veröffentlicht in:	Journal of assisted reproduction and genetics 2015-07, Vol.32 (7), p.1097-1104
Hauptverfasser:	Yan, Wen-jie, Mu, Yang, Yu, Nan, Yi, Tai-lang, Zhang, Yi, Pang, Xiang-li, Cheng, Dan, Yang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Diabetes Diet Diet, High-Fat - adverse effects Gynecology Homeostasis Hormones Hospitals Human Genetics Hypoglycemic Agents - pharmacology Infertility Insulin resistance Male Medical research Medicine Medicine & Public Health Metabolic disorders Metabolic syndrome Metformin - pharmacology Morphology Motility Obesity Obesity - etiology Obesity - physiopathology Protective Agents - pharmacology Rats, Sprague-Dawley Reproductive Medicine Reproductive Physiology and Disease Sperm Motility - drug effects Spermatogenesis Spermatogenesis - drug effects Testes Testis - drug effects Testis - pathology Testis - physiology Testosterone Weight control
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