EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report
EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very i...
Gespeichert in:
| Veröffentlicht in: | The Korean journal of internal medicine 2002-03, Vol.17 (1), p.65-68 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 68 |
|---|---|
| container_issue | 1 |
| container_start_page | 65 |
| container_title | The Korean journal of internal medicine |
| container_volume | 17 |
| creator | Ahn, Hae Lyun Jo, Young Il Choi, Young Suk Lee, Jung Yeon Lee, Hae Woon Kim, Seong Ryul Sim, Joon Lee, Weon Jin, Chun Jo |
| description | EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin. |
| doi_str_mv | 10.3904/kjim.2002.17.1.65 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531650</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>12014216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3105-de9a6707ff52dd760c473ff7ada07a8434c5053605c23e44668a152c81eed9823</originalsourceid><addsrcrecordid>eNpVkNtKAzEURYMotlY_wBfJD8yYe6YIQtF6gYIv9dWQ5mLTdiZDZir0701p8fJ0OJy999ksAK4xKukYsdv1KtQlQYiUWJa4FPwEDPPKCyFYdQqGmBBRUIroAFx03QohIVFFz8EAE4QZwWIIPqaP80lhXesa65oetp3b2tgvU6wX0ez6mA9BQxMbH1LtLFzsYLdt242rs1z3ITYwerjWja53JjR3MIt152BybUz9JTjzetO5q-Mcgfen6fzhpZi9Pb8-TGaFoTj3tW6sczfpPSfWSoEMk9R7qa1GUleMMsMRpwJxQ6hjTIhKY05MhZ2z44rQEbg_5LbbRW5pcrekN6pNodZpp6IO6v-lCUv1Gb8U4xQLjnIAPgSYFLsuOf_jxUjtYas9bLWHrbBUWAmePTd_n_46jnTpN3Xjfks</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central Open Access</source><source>PubMed Central</source><creator>Ahn, Hae Lyun ; Jo, Young Il ; Choi, Young Suk ; Lee, Jung Yeon ; Lee, Hae Woon ; Kim, Seong Ryul ; Sim, Joon ; Lee, Weon ; Jin, Chun Jo</creator><creatorcontrib>Ahn, Hae Lyun ; Jo, Young Il ; Choi, Young Suk ; Lee, Jung Yeon ; Lee, Hae Woon ; Kim, Seong Ryul ; Sim, Joon ; Lee, Weon ; Jin, Chun Jo</creatorcontrib><description>EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.</description><identifier>ISSN: 1226-3303</identifier><identifier>EISSN: 2005-6648</identifier><identifier>DOI: 10.3904/kjim.2002.17.1.65</identifier><identifier>PMID: 12014216</identifier><language>eng</language><publisher>Korea (South): Korean Association of Internal Medicine</publisher><subject>Anti-Bacterial Agents - pharmacology ; Anticoagulants - adverse effects ; Anticoagulants - pharmacology ; Case Report ; Edetic Acid - adverse effects ; Female ; Humans ; Kanamycin - pharmacology ; Middle Aged ; Platelet Aggregation - drug effects ; Platelet Aggregation Inhibitors - therapeutic use ; Platelet Count ; Thrombocytopenia - blood ; Thrombocytopenia - chemically induced</subject><ispartof>The Korean journal of internal medicine, 2002-03, Vol.17 (1), p.65-68</ispartof><rights>Copyright © 2002 The Korean Association of Internal Medicine 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3105-de9a6707ff52dd760c473ff7ada07a8434c5053605c23e44668a152c81eed9823</citedby><cites>FETCH-LOGICAL-c3105-de9a6707ff52dd760c473ff7ada07a8434c5053605c23e44668a152c81eed9823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531650/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531650/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12014216$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahn, Hae Lyun</creatorcontrib><creatorcontrib>Jo, Young Il</creatorcontrib><creatorcontrib>Choi, Young Suk</creatorcontrib><creatorcontrib>Lee, Jung Yeon</creatorcontrib><creatorcontrib>Lee, Hae Woon</creatorcontrib><creatorcontrib>Kim, Seong Ryul</creatorcontrib><creatorcontrib>Sim, Joon</creatorcontrib><creatorcontrib>Lee, Weon</creatorcontrib><creatorcontrib>Jin, Chun Jo</creatorcontrib><title>EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report</title><title>The Korean journal of internal medicine</title><addtitle>Korean J Intern Med</addtitle><description>EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Anticoagulants - adverse effects</subject><subject>Anticoagulants - pharmacology</subject><subject>Case Report</subject><subject>Edetic Acid - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Kanamycin - pharmacology</subject><subject>Middle Aged</subject><subject>Platelet Aggregation - drug effects</subject><subject>Platelet Aggregation Inhibitors - therapeutic use</subject><subject>Platelet Count</subject><subject>Thrombocytopenia - blood</subject><subject>Thrombocytopenia - chemically induced</subject><issn>1226-3303</issn><issn>2005-6648</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkNtKAzEURYMotlY_wBfJD8yYe6YIQtF6gYIv9dWQ5mLTdiZDZir0701p8fJ0OJy999ksAK4xKukYsdv1KtQlQYiUWJa4FPwEDPPKCyFYdQqGmBBRUIroAFx03QohIVFFz8EAE4QZwWIIPqaP80lhXesa65oetp3b2tgvU6wX0ez6mA9BQxMbH1LtLFzsYLdt242rs1z3ITYwerjWja53JjR3MIt152BybUz9JTjzetO5q-Mcgfen6fzhpZi9Pb8-TGaFoTj3tW6sczfpPSfWSoEMk9R7qa1GUleMMsMRpwJxQ6hjTIhKY05MhZ2z44rQEbg_5LbbRW5pcrekN6pNodZpp6IO6v-lCUv1Gb8U4xQLjnIAPgSYFLsuOf_jxUjtYas9bLWHrbBUWAmePTd_n_46jnTpN3Xjfks</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Ahn, Hae Lyun</creator><creator>Jo, Young Il</creator><creator>Choi, Young Suk</creator><creator>Lee, Jung Yeon</creator><creator>Lee, Hae Woon</creator><creator>Kim, Seong Ryul</creator><creator>Sim, Joon</creator><creator>Lee, Weon</creator><creator>Jin, Chun Jo</creator><general>Korean Association of Internal Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope></search><sort><creationdate>20020301</creationdate><title>EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report</title><author>Ahn, Hae Lyun ; Jo, Young Il ; Choi, Young Suk ; Lee, Jung Yeon ; Lee, Hae Woon ; Kim, Seong Ryul ; Sim, Joon ; Lee, Weon ; Jin, Chun Jo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3105-de9a6707ff52dd760c473ff7ada07a8434c5053605c23e44668a152c81eed9823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Anticoagulants - adverse effects</topic><topic>Anticoagulants - pharmacology</topic><topic>Case Report</topic><topic>Edetic Acid - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Kanamycin - pharmacology</topic><topic>Middle Aged</topic><topic>Platelet Aggregation - drug effects</topic><topic>Platelet Aggregation Inhibitors - therapeutic use</topic><topic>Platelet Count</topic><topic>Thrombocytopenia - blood</topic><topic>Thrombocytopenia - chemically induced</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahn, Hae Lyun</creatorcontrib><creatorcontrib>Jo, Young Il</creatorcontrib><creatorcontrib>Choi, Young Suk</creatorcontrib><creatorcontrib>Lee, Jung Yeon</creatorcontrib><creatorcontrib>Lee, Hae Woon</creatorcontrib><creatorcontrib>Kim, Seong Ryul</creatorcontrib><creatorcontrib>Sim, Joon</creatorcontrib><creatorcontrib>Lee, Weon</creatorcontrib><creatorcontrib>Jin, Chun Jo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Korean journal of internal medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahn, Hae Lyun</au><au>Jo, Young Il</au><au>Choi, Young Suk</au><au>Lee, Jung Yeon</au><au>Lee, Hae Woon</au><au>Kim, Seong Ryul</au><au>Sim, Joon</au><au>Lee, Weon</au><au>Jin, Chun Jo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report</atitle><jtitle>The Korean journal of internal medicine</jtitle><addtitle>Korean J Intern Med</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>17</volume><issue>1</issue><spage>65</spage><epage>68</epage><pages>65-68</pages><issn>1226-3303</issn><eissn>2005-6648</eissn><abstract>EDTA-dependent pseudothrombocytopenia (PTCP) is the phenomenon of a spurious low platelet count due to EDTA-induced aggregation of platelets. Since the failure to recognize EDTA-dependent PTCP may result in incorrect diagnosis and inappropriate treatment, the recognition of this phenomenon is very important. We report an insidious case of EDTA-dependent PTCP confirmed by supplementation of kanamycin to anticoagulant in a 53-year-old women. Although sodium citrate and heparin usually prevented the aggregation of platelets in EDTA-dependent PTCP patients, these anticoagulants failed in preventing PTCP in our case. EDTA-dependent PTCP was confirmed by the findings that the clumping of platelets on microscopic evaluation was found in EDTA-anticoagulated blood samples, whereas thrombocytopenia and platelet aggregation were not revealed in the sample supplemented with kanamycin.</abstract><cop>Korea (South)</cop><pub>Korean Association of Internal Medicine</pub><pmid>12014216</pmid><doi>10.3904/kjim.2002.17.1.65</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1226-3303 |
| ispartof | The Korean journal of internal medicine, 2002-03, Vol.17 (1), p.65-68 |
| issn | 1226-3303 2005-6648 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4531650 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Anti-Bacterial Agents - pharmacology Anticoagulants - adverse effects Anticoagulants - pharmacology Case Report Edetic Acid - adverse effects Female Humans Kanamycin - pharmacology Middle Aged Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - therapeutic use Platelet Count Thrombocytopenia - blood Thrombocytopenia - chemically induced |
| title | EDTA-dependent pseudothrombocytopenia confirmed by supplementation of kanamycin; a case report |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T19%3A20%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=EDTA-dependent%20pseudothrombocytopenia%20confirmed%20by%20supplementation%20of%20kanamycin;%20a%20case%20report&rft.jtitle=The%20Korean%20journal%20of%20internal%20medicine&rft.au=Ahn,%20Hae%20Lyun&rft.date=2002-03-01&rft.volume=17&rft.issue=1&rft.spage=65&rft.epage=68&rft.pages=65-68&rft.issn=1226-3303&rft.eissn=2005-6648&rft_id=info:doi/10.3904/kjim.2002.17.1.65&rft_dat=%3Cpubmed_cross%3E12014216%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/12014216&rfr_iscdi=true |