The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats
Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naringin (NG) or treadmill exercise (EX) on osteoporosis, however, reports about effects of NG pl...
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| description | Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naringin (NG) or treadmill exercise (EX) on osteoporosis, however, reports about effects of NG plus EX on osteoporosis are limited. This study was designed to investigate the impact of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized (OVX) rats. Three months after bilateral ovariectomy, Seventy-five rats were randomly assigned to the following treatment groups: OVX, sham-operated (SHAM), NG, EX, or NG plus EX treatment. Treatments were administered for 60 days. Bone metabolism, bone mineral density, trabecular bone parameters, immunohistochemistry and the bone strength were evaluated. Compared to the OVX groups, all treatments increased bone volume (BV/TV), trabecula number (Tb.N), trabecula thickness (Tb.Th), bone mineral density (BMD) and mechanical strength. NG + EX showed the strongest effects on BV/TV, Tb.Th and biomechanical strength. Additionally, decreased C-terminal telopeptides of type I collagen (CTX-1) and enhanced osteocalcin (OCN) expression were observed in the NG + EX group. The present study demonstrates that the NG + EX may have a therapeutic advantage over each monotherapy for the treatment of osteoporosis. |
| doi_str_mv | 10.1038/srep13009 |
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Previous studies have demonstrated the effect of naringin (NG) or treadmill exercise (EX) on osteoporosis, however, reports about effects of NG plus EX on osteoporosis are limited. This study was designed to investigate the impact of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized (OVX) rats. Three months after bilateral ovariectomy, Seventy-five rats were randomly assigned to the following treatment groups: OVX, sham-operated (SHAM), NG, EX, or NG plus EX treatment. Treatments were administered for 60 days. Bone metabolism, bone mineral density, trabecular bone parameters, immunohistochemistry and the bone strength were evaluated. Compared to the OVX groups, all treatments increased bone volume (BV/TV), trabecula number (Tb.N), trabecula thickness (Tb.Th), bone mineral density (BMD) and mechanical strength. NG + EX showed the strongest effects on BV/TV, Tb.Th and biomechanical strength. Additionally, decreased C-terminal telopeptides of type I collagen (CTX-1) and enhanced osteocalcin (OCN) expression were observed in the NG + EX group. The present study demonstrates that the NG + EX may have a therapeutic advantage over each monotherapy for the treatment of osteoporosis.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep13009</identifier><identifier>PMID: 26260240</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/337 ; 692/163 ; 692/308/153 ; Animals ; Bone and Bones - drug effects ; Bone and Bones - pathology ; Bone density ; Bone Density - drug effects ; Bone mass ; Bone mineral density ; Bone strength ; Bone turnover ; Cancellous bone ; Collagen (type I) ; Combined treatment ; Female ; Fitness equipment ; Flavanones - administration & dosage ; Humanities and Social Sciences ; Humans ; Immunohistochemistry ; Mechanical properties ; multidisciplinary ; Osteocalcin ; Osteoporosis ; Osteoporosis - drug therapy ; Osteoporosis - pathology ; Ovariectomy ; Physical Conditioning, Animal ; Rats ; Rats, Sprague-Dawley ; Rodents ; Science</subject><ispartof>Scientific reports, 2015-08, Vol.5 (1), p.13009-13009, Article 13009</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Aug 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-d0948b5889193b23b5e5d7f55400e07579c2d927b24e2e9869af509394eeef93</citedby><cites>FETCH-LOGICAL-c438t-d0948b5889193b23b5e5d7f55400e07579c2d927b24e2e9869af509394eeef93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531319/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531319/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,725,778,782,862,883,27907,27908,41103,42172,51559,53774,53776</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26260240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SUN, Xiaolei</creatorcontrib><creatorcontrib>Fengbo, LI</creatorcontrib><creatorcontrib>Xinlong, MA</creatorcontrib><creatorcontrib>Jianxiong, MA</creatorcontrib><creatorcontrib>ZHAO, Bin</creatorcontrib><creatorcontrib>ZHANG, Yang</creatorcontrib><creatorcontrib>Yanjun, LI</creatorcontrib><creatorcontrib>Jianwei, LV</creatorcontrib><creatorcontrib>MENG, Xinmin</creatorcontrib><title>The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naringin (NG) or treadmill exercise (EX) on osteoporosis, however, reports about effects of NG plus EX on osteoporosis are limited. This study was designed to investigate the impact of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized (OVX) rats. Three months after bilateral ovariectomy, Seventy-five rats were randomly assigned to the following treatment groups: OVX, sham-operated (SHAM), NG, EX, or NG plus EX treatment. Treatments were administered for 60 days. Bone metabolism, bone mineral density, trabecular bone parameters, immunohistochemistry and the bone strength were evaluated. Compared to the OVX groups, all treatments increased bone volume (BV/TV), trabecula number (Tb.N), trabecula thickness (Tb.Th), bone mineral density (BMD) and mechanical strength. NG + EX showed the strongest effects on BV/TV, Tb.Th and biomechanical strength. Additionally, decreased C-terminal telopeptides of type I collagen (CTX-1) and enhanced osteocalcin (OCN) expression were observed in the NG + EX group. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SUN, Xiaolei</au><au>Fengbo, LI</au><au>Xinlong, MA</au><au>Jianxiong, MA</au><au>ZHAO, Bin</au><au>ZHANG, Yang</au><au>Yanjun, LI</au><au>Jianwei, LV</au><au>MENG, Xinmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-08-11</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>13009</spage><epage>13009</epage><pages>13009-13009</pages><artnum>13009</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Osteoporosis is a disease characterized by low bone mass and progressive destruction of bone microstructure, resulting in increased the risk of fracture. Previous studies have demonstrated the effect of naringin (NG) or treadmill exercise (EX) on osteoporosis, however, reports about effects of NG plus EX on osteoporosis are limited. This study was designed to investigate the impact of combined treatment with naringin and treadmill exercise on osteoporosis in ovariectomized (OVX) rats. Three months after bilateral ovariectomy, Seventy-five rats were randomly assigned to the following treatment groups: OVX, sham-operated (SHAM), NG, EX, or NG plus EX treatment. Treatments were administered for 60 days. Bone metabolism, bone mineral density, trabecular bone parameters, immunohistochemistry and the bone strength were evaluated. Compared to the OVX groups, all treatments increased bone volume (BV/TV), trabecula number (Tb.N), trabecula thickness (Tb.Th), bone mineral density (BMD) and mechanical strength. NG + EX showed the strongest effects on BV/TV, Tb.Th and biomechanical strength. Additionally, decreased C-terminal telopeptides of type I collagen (CTX-1) and enhanced osteocalcin (OCN) expression were observed in the NG + EX group. The present study demonstrates that the NG + EX may have a therapeutic advantage over each monotherapy for the treatment of osteoporosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26260240</pmid><doi>10.1038/srep13009</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/337 692/163 692/308/153 Animals Bone and Bones - drug effects Bone and Bones - pathology Bone density Bone Density - drug effects Bone mass Bone mineral density Bone strength Bone turnover Cancellous bone Collagen (type I) Combined treatment Female Fitness equipment Flavanones - administration & dosage Humanities and Social Sciences Humans Immunohistochemistry Mechanical properties multidisciplinary Osteocalcin Osteoporosis Osteoporosis - drug therapy Osteoporosis - pathology Ovariectomy Physical Conditioning, Animal Rats Rats, Sprague-Dawley Rodents Science |
| title | The Effects of Combined Treatment with Naringin and Treadmill Exercise on Osteoporosis in Ovariectomized Rats |
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