The antioxidant compound tert-butylhydroquinone activates Akt in myocardium, suppresses apoptosis and ameliorates pressure overload-induced cardiac dysfunction

Tert-butylhydroquinone (TBHQ) is an antioxidant compound which shows multiple cytoprotective actions. We evaluated the effects of TBHQ on pathological cardiac remodeling and dysfunction induced by chronic overload. Pressure overload was created by transverse aortic constriction (TAC) in male C57BL/6...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Scientific reports 2015-08, Vol.5 (1), p.13005-13005, Article 13005
Hauptverfasser:	Zhang, Yongtao, Fang Liu, Fang, Bi, Xiaolei, Wang, Shuangxi, Wu, Xiao, Jiang, Fan
Format:	Artikel
Sprache:	eng
Schlagworte:	631/154/436 692/699/75 AKT protein AMP AMP-activated protein kinase Androstadienes - administration & dosage Animals Antioxidants Antioxidants - administration & dosage Aorta Apoptosis Apoptosis - drug effects Arterial Pressure - drug effects Cardiomyocytes Glycogen Glycogen synthase kinase 3 Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 beta Heart - drug effects Heart - physiopathology Heart diseases Heart Diseases - drug therapy Heart Diseases - genetics Heart Diseases - physiopathology Humanities and Social Sciences Humans Hydroquinones - administration & dosage Kinases Male Mice multidisciplinary Myocardium Myocardium - pathology Myocytes NF-E2-Related Factor 2 - genetics Oncogene Protein v-akt - biosynthesis Oncogene Protein v-akt - genetics Oxidative Stress - drug effects Oxidizing agents Phosphorylation Phosphorylation - drug effects Pressure Rapamycin Rodents Science t-Butylhydroquinone TOR protein Ventricle Wortmannin
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!