Complementation of DNA repair in xeroderma pigmentosum group A cell extracts by a protein with affinity for damaged DNA

Complementation group A of xeroderma pigmentosum (XP) represents one of the most prevalent and serious forms of this cancer‐prone disorder. Because of a marked defect in DNA excision repair, cells from individuals with XP‐A are hypersensitive to the toxic and mutagenic effects of ultraviolet light a...

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Veröffentlicht in:	The EMBO journal 1991-12, Vol.10 (12), p.3913-3921
Hauptverfasser:	Robins, P., Jones, C.J., Biggerstaff, M., Lindahl, T., Wood, R.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Sequence Animals Autoradiography Biological and medical sciences Blotting, Western Cattle Cell Line Child Chromatography, Liquid Dermatology DNA DNA - metabolism DNA Damage DNA Repair - genetics Electrophoresis, Polyacrylamide Gel Female Genetic Complementation Test Hereditary diseases of the skin. Congenital diseases of the skin. Haemangioma of the skin, of mucosae and of soft tissue Hot Temperature Humans Male Medical sciences Molecular Sequence Data Plasmids U.V. radiation xeroderma pigmentosum Xeroderma Pigmentosum - genetics Xeroderma Pigmentosum - metabolism XP-A protein
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