Dspp-independent Effects of Transgenic Trps1 Overexpression on Dentin Formation

The Trps1 transcription factor is highly expressed in dental mesenchyme and preodontoblasts, while in mature, secretory odontoblasts, it is expressed at low levels. Previously, we have shown that high Trps1 levels in mature odontoblasts impair their function in vitro and in vivo. Col1a1-Trps1 transg...

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Veröffentlicht in:	Journal of dental research 2015-08, Vol.94 (8), p.1128-1134
Hauptverfasser:	Mobley, C.G., Kuzynski, M., Zhang, H., Jani, P., Qin, C., Napierala, D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Collagen (type I) Computed tomography Data analysis Dentin Dentin - growth & development Dentin - metabolism Dentinogenesis Dentistry Down-Regulation Dspp protein Extracellular matrix Extracellular Matrix Proteins - metabolism GATA Transcription Factors - metabolism Genes Histology Homeostasis Hypophosphatemia Immunoglobulins Immunohistochemistry Laboratory animals Mandible - diagnostic imaging Mesenchyme Mice Mice, Transgenic Mineralization Mutation Odontoblasts Odontoblasts - metabolism Phenotype Phenotypes Phosphoproteins - metabolism Research Reports Rickets Secretion Sialoglycoproteins - metabolism Studies Transgenic mice X-Ray Microtomography
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