Natural Anti-Infective Pulmonary Proteins: In Vivo Cooperative Action of Surfactant Protein SP-A and the Lung Antimicrobial Peptide SP-BN

The anionic antimicrobial peptide SP-B(N), derived from the N-terminal saposin-like domain of the surfactant protein (SP)-B proprotein, and SP-A are lung anti-infective proteins. SP-A-deficient mice are more susceptible than wild-type mice to lung infections, and bacterial killing is enhanced in tra...

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Veröffentlicht in:	The Journal of immunology (1950) 2015-08, Vol.195 (4), p.1628-1636
Hauptverfasser:	Coya, Juan Manuel, Akinbi, Henry T, Sáenz, Alejandra, Yang, Li, Weaver, Timothy E, Casals, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology Antimicrobial Cationic Peptides - pharmacology Cytokines - metabolism Disease Models, Animal Drug Synergism Humans Hydrogen-Ion Concentration Klebsiella Infections - immunology Klebsiella Infections - metabolism Klebsiella Infections - microbiology Klebsiella pneumoniae Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - immunology Lung - drug effects Lung - immunology Lung - microbiology Lung - pathology Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Male Mice Mice, Knockout Neutrophil Infiltration Protein Binding Pulmonary Surfactant-Associated Protein A - genetics Pulmonary Surfactant-Associated Protein A - metabolism Pulmonary Surfactant-Associated Protein A - pharmacology Pulmonary Surfactant-Associated Protein B - genetics Pulmonary Surfactant-Associated Protein B - metabolism Pulmonary Surfactant-Associated Protein B - pharmacology Pulmonary Surfactant-Associated Proteins - genetics Pulmonary Surfactant-Associated Proteins - metabolism Pulmonary Surfactant-Associated Proteins - pharmacology Recombinant Proteins - genetics Recombinant Proteins - metabolism Recombinant Proteins - pharmacology
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