Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators
Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been...
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| creator | Alaaeddine, Nada Wardi, Layal Sidaoui, Joseph Boutros, George Hilal, George Serhal, Rim Ezzeddine, Salah |
| description | Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of patients. The expression of S100A8, S100A9, S100A8/A9, CCL20, and IL-17, detected by ELISA, is significantly increased in NASH patients with fibrosis in comparison with controls. But, in NASH patients, S100A9, S100A8/A9, and IL-17 only are significantly elevated in comparison with controls. The same, on the mRNA level, expression of IL-17, detected by RT-PCR, is significantly elevated in NASH patients in comparison with controls. Therefore, there is a direct link between the expression of IL-17, CCL20, telomerase, S100A8, and S100A9 in the fibrotic condition and the progression towards cancer. |
| doi_str_mv | 10.1155/2015/850246 |
| format | Article |
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Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of patients. The expression of S100A8, S100A9, S100A8/A9, CCL20, and IL-17, detected by ELISA, is significantly increased in NASH patients with fibrosis in comparison with controls. But, in NASH patients, S100A9, S100A8/A9, and IL-17 only are significantly elevated in comparison with controls. The same, on the mRNA level, expression of IL-17, detected by RT-PCR, is significantly elevated in NASH patients in comparison with controls. Therefore, there is a direct link between the expression of IL-17, CCL20, telomerase, S100A8, and S100A9 in the fibrotic condition and the progression towards cancer.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2015/850246</identifier><identifier>PMID: 26273651</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adult ; Biomarkers - metabolism ; Biopsy ; Chemokines ; Cytokines ; Cytokines - metabolism ; Female ; Health aspects ; Hepatitis ; Hospitals ; Humans ; Inflammation ; Inflammation Mediators - metabolism ; Inflammatory diseases ; Laboratories ; Lebanon - epidemiology ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Male ; Mortality ; Non-alcoholic Fatty Liver Disease - diagnosis ; Non-alcoholic Fatty Liver Disease - epidemiology ; Non-alcoholic Fatty Liver Disease - metabolism ; Physiological aspects ; Precancerous Conditions - epidemiology ; Precancerous Conditions - metabolism ; Prevalence ; Proteins ; Reproducibility of Results ; Risk Factors ; Sensitivity and Specificity ; Telomerase ; Telomerase - metabolism ; Tumors</subject><ispartof>BioMed research international, 2015-01, Vol.2015 (2015), p.1-9</ispartof><rights>Copyright © 2015 Rim Serhal et al.</rights><rights>COPYRIGHT 2015 John Wiley & Sons, Inc.</rights><rights>Copyright © 2015 Rim Serhal et al. Rim Serhal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2015 Rim Serhal et al. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c528t-7f6dde29984fa615f1cd48ce36987823c73072dd390898ba50ccdc2588821b993</citedby><cites>FETCH-LOGICAL-c528t-7f6dde29984fa615f1cd48ce36987823c73072dd390898ba50ccdc2588821b993</cites><orcidid>0000-0003-3429-2673</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529930/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529930/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26273651$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Salomone, Federico</contributor><creatorcontrib>Alaaeddine, Nada</creatorcontrib><creatorcontrib>Wardi, Layal</creatorcontrib><creatorcontrib>Sidaoui, Joseph</creatorcontrib><creatorcontrib>Boutros, George</creatorcontrib><creatorcontrib>Hilal, George</creatorcontrib><creatorcontrib>Serhal, Rim</creatorcontrib><creatorcontrib>Ezzeddine, Salah</creatorcontrib><title>Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of patients. The expression of S100A8, S100A9, S100A8/A9, CCL20, and IL-17, detected by ELISA, is significantly increased in NASH patients with fibrosis in comparison with controls. But, in NASH patients, S100A9, S100A8/A9, and IL-17 only are significantly elevated in comparison with controls. The same, on the mRNA level, expression of IL-17, detected by RT-PCR, is significantly elevated in NASH patients in comparison with controls. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alaaeddine, Nada</au><au>Wardi, Layal</au><au>Sidaoui, Joseph</au><au>Boutros, George</au><au>Hilal, George</au><au>Serhal, Rim</au><au>Ezzeddine, Salah</au><au>Salomone, Federico</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>2015</volume><issue>2015</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Nonalcoholic steatohepatitis or NASH is an excessive accumulation of fat in hepatocytes accompanied by inflammation and hepatic injury. Proinflammatory molecules such as IL-17, CCL20, S100A8, S100A9, and S100A8/A9 have been shown to be implicated in many types of cancer. Telomerase activity has been found to be associated with chronic inflammation and cancer. NASH can progress to fibrosis then cirrhosis and finally to hepatocellular carcinoma (HCC). Our objective is to try to find a relation between inflammation and the progression of NASH into HCC. We found that there was a significant elevation in the telomerase activity, detected by real-time PCR, between NASH and fibrotic NASH in the liver biopsies of patients. The expression of S100A8, S100A9, S100A8/A9, CCL20, and IL-17, detected by ELISA, is significantly increased in NASH patients with fibrosis in comparison with controls. But, in NASH patients, S100A9, S100A8/A9, and IL-17 only are significantly elevated in comparison with controls. The same, on the mRNA level, expression of IL-17, detected by RT-PCR, is significantly elevated in NASH patients in comparison with controls. Therefore, there is a direct link between the expression of IL-17, CCL20, telomerase, S100A8, and S100A9 in the fibrotic condition and the progression towards cancer.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>26273651</pmid><doi>10.1155/2015/850246</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3429-2673</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biomarkers - metabolism Biopsy Chemokines Cytokines Cytokines - metabolism Female Health aspects Hepatitis Hospitals Humans Inflammation Inflammation Mediators - metabolism Inflammatory diseases Laboratories Lebanon - epidemiology Liver cancer Liver cirrhosis Liver diseases Male Mortality Non-alcoholic Fatty Liver Disease - diagnosis Non-alcoholic Fatty Liver Disease - epidemiology Non-alcoholic Fatty Liver Disease - metabolism Physiological aspects Precancerous Conditions - epidemiology Precancerous Conditions - metabolism Prevalence Proteins Reproducibility of Results Risk Factors Sensitivity and Specificity Telomerase Telomerase - metabolism Tumors |
| title | Nonalcoholic Steatohepatitis: Involvement of the Telomerase and Proinflammatory Mediators |
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