Combining Foxc2 and Connexin37 deletions in mice leads to severe defects in lymphatic vascular growth and remodeling

Connexins (Cxs), proteins that are vital for intercellular communication in vertebrates, have recently been shown to play a critical role in lymphatic development. However, our knowledge is currently limited regarding the functional relationships of Cxs with other proteins and signaling pathways. Ce...

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Veröffentlicht in:	Developmental biology 2015-09, Vol.405 (1), p.33-46
Hauptverfasser:	Kanady, John D., Munger, Stephanie J., Witte, Marlys H., Simon, Alexander M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Body Patterning Colon - pathology Connexins - deficiency Connexins - metabolism Craniofacial Abnormalities - embryology Craniofacial Abnormalities - pathology Cx37 Edema - pathology Embryo, Mammalian - abnormalities Embryo, Mammalian - pathology Epithelial Cells - metabolism Epithelial Cells - pathology Forkhead Transcription Factors - deficiency Forkhead Transcription Factors - metabolism Foxc2 Gap Junction alpha-4 Protein Gene Deletion Intestine, Small - pathology Lymphangiogenesis Lymphangioma - pathology Lymphatic valve Lymphatic Vessels - abnormalities Lymphatic Vessels - embryology Lymphatic Vessels - pathology Lymphedema Lymphography Mesentery - pathology Mice, Inbred C57BL Mitosis Skin - embryology Skin - pathology Vascular development
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