A Single miRNA-mRNA Interaction Affects the Immune Response in a Context- and Cell-Type-Specific Manner

MicroRNA (miRNA)-dependent regulation of gene expression confers robustness to cellular phenotypes and controls responses to extracellular stimuli. Although a single miRNA can regulate expression of hundreds of target genes, it is unclear whether any of its distinct biological functions can be due t...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2015-07, Vol.43 (1), p.52-64
Hauptverfasser:	Lu, Li-Fan, Gasteiger, Georg, Yu, I-Shing, Chaudhry, Ashutosh, Hsin, Jing-Ping, Lu, Yuheng, Bos, Paula D., Lin, Ling-Li, Zawislak, Carolyn L., Cho, Sunglim, Sun, Joseph C., Leslie, Christina S., Lin, Shu-Wha, Rudensky, Alexander Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Binding sites CD8-Positive T-Lymphocytes - immunology Cytokines Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Gene expression Gene Expression Profiling Herpesviridae Infections - immunology Herpesviridae Infections - virology Immune system Infections Killer Cells, Natural - immunology Killer Cells, Natural - transplantation Lymphocytes Lymphocytic Choriomeningitis - immunology Lymphocytic Choriomeningitis - virology Lymphocytic choriomeningitis virus - immunology Mice Mice, Inbred C57BL Mice, Knockout MicroRNAs - genetics Muromegalovirus - immunology Mutation RNA, Messenger - genetics Rodents Software Studies Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins - genetics T cell receptors T-Lymphocytes, Regulatory - immunology Viral infections
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