Age, atherosclerosis and type 2 diabetes reduce human mesenchymal stromal cell-mediated T-cell suppression

To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for t...

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Veröffentlicht in:	Stem cell research & therapy 2015-08, Vol.6 (1), p.140-140, Article 140
Hauptverfasser:	Kizilay Mancini, Ozge, Shum-Tim, Dominique, Stochaj, Ursula, Correa, José A, Colmegna, Inés
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Age Factors Aged Atherosclerosis Atherosclerosis - pathology CD4-Positive T-Lymphocytes - cytology CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - metabolism Cell Proliferation Cells, Cultured Coculture Techniques Diabetes Mellitus, Type 2 - pathology Female Health aspects Heart diseases Humans Linear Models Male Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Methods Middle Aged Patient outcomes Physiological aspects Severity of Illness Index Short Report Stem cells T cells Type 2 diabetes
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Zusammenfassung:	To this end human MSCs were isolated from adipose tissue and the MSC:CD4(+) T-cell suppression was assessed in a co-culture system. In summary, this study demonstrates that advanced age, atherosclerosis and type 2 diabetes mellitus reduce the functional potency of MSCs. Optimizing the criteria for the selection of MSC donors could enhance the results of cell-based therapies.
ISSN:	1757-6512 1757-6512
DOI:	10.1186/s13287-015-0127-9