Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results
Objective To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well‐characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls. Methods Data on cardiovascular risk factors in prim...
Gespeichert in:
| Veröffentlicht in: | Arthritis care & research (2010) 2014-05, Vol.66 (5), p.757-764 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 764 |
|---|---|
| container_issue | 5 |
| container_start_page | 757 |
| container_title | Arthritis care & research (2010) |
| container_volume | 66 |
| creator | Juarez, M. Toms, T. E. Pablo, P. Mitchell, S. Bowman, S. Nightingale, P. Price, E. J. Griffiths, B. Hunter, J. Gupta, M. Bombardieri, M. Sutcliffe, N. Pitzalis, C. Pease, C. Andrews, J. Emery, P. Regan, M. Giles, I. Isenberg, D. Moots, R. Collins, K. S. Ng, W. F. Kitas, G. D. |
| description | Objective
To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well‐characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.
Methods
Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.
Results
Primary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age‐ and sex‐matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.
Conclusion
Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age‐ and sex‐matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS. |
| doi_str_mv | 10.1002/acr.22227 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4529667</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1530957263</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4157-8b35bee57246d07af221e8fe82c853b3dc278c4fffca8852b463bcdc435a58273</originalsourceid><addsrcrecordid>eNp9kc1O3DAURi0EAgSz4AWQd6WLgfgv8XRRCY1KW4EEGhjBznKcm8E0icFOqGbLQ_ECfbF6yDCCBdyFbekeHX_Sh9AeSQ5JktAjbfwhjZOtoW1KBBnyVMj11ZvfbKFBCHdJHEalZKNNtEW5zDKakG30NNa-sO5RB9NV2uOJDX_wiTat8wHbBl-7GuJp21t84W2t_Rxf3v17nnlovgR8OW8KH4lveNrYFgp8aptZ4erPWDyBmQ1tXE4gdFUbdtFGqasAg-W9g6YnP67Gv4Zn5z9_j4_PhoYTkQ1lzkQOIDLK0yLJdEkpAVmCpEYKlrPC0EwaXpal0VIKmvOU5aYwnAktJM3YDvree--7vIbCQNN6Xan7Pqpy2qr3m8beqpl7VFzQUZouBAdLgXcPHYRW1TYYqCrdgOuCIoIlo5gvZRH92qPGuxA8lKtvSKIWtalYm3qpLbL7b3OtyNeSInDUA39tBfOPTep4POmV_wEHOKXu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1530957263</pqid></control><display><type>article</type><title>Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Juarez, M. ; Toms, T. E. ; Pablo, P. ; Mitchell, S. ; Bowman, S. ; Nightingale, P. ; Price, E. J. ; Griffiths, B. ; Hunter, J. ; Gupta, M. ; Bombardieri, M. ; Sutcliffe, N. ; Pitzalis, C. ; Pease, C. ; Andrews, J. ; Emery, P. ; Regan, M. ; Giles, I. ; Isenberg, D. ; Moots, R. ; Collins, K. S. ; Ng, W. F. ; Kitas, G. D.</creator><creatorcontrib>Juarez, M. ; Toms, T. E. ; Pablo, P. ; Mitchell, S. ; Bowman, S. ; Nightingale, P. ; Price, E. J. ; Griffiths, B. ; Hunter, J. ; Gupta, M. ; Bombardieri, M. ; Sutcliffe, N. ; Pitzalis, C. ; Pease, C. ; Andrews, J. ; Emery, P. ; Regan, M. ; Giles, I. ; Isenberg, D. ; Moots, R. ; Collins, K. S. ; Ng, W. F. ; Kitas, G. D. ; UK Primary Sjögren’s Syndrome Registry ; on behalf of the UK Primary Sjögren's Syndrome Registry</creatorcontrib><description>Objective
To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well‐characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.
Methods
Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.
Results
Primary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age‐ and sex‐matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.
Conclusion
Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age‐ and sex‐matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.</description><identifier>ISSN: 2151-464X</identifier><identifier>EISSN: 2151-4658</identifier><identifier>DOI: 10.1002/acr.22227</identifier><identifier>PMID: 24877201</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Cardiovascular Diseases - diagnosis ; Cardiovascular Diseases - epidemiology ; Cohort Studies ; Female ; Humans ; Hypertension - diagnosis ; Hypertension - epidemiology ; Hypertriglyceridemia - diagnosis ; Hypertriglyceridemia - epidemiology ; Male ; Middle Aged ; Prospective Studies ; Registries ; Risk Factors ; Sjogren's Syndrome - diagnosis ; Sjogren's Syndrome - epidemiology ; SjöGren's Syndrome ; United Kingdom - epidemiology</subject><ispartof>Arthritis care & research (2010), 2014-05, Vol.66 (5), p.757-764</ispartof><rights>2014 The Authors. Arthritis Care & Research is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology.</rights><rights>2014 The Authors. Arthritis Care & Research is published by Wiley Periodicals, Inc. on behalf of the American College of Rheumatology. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4157-8b35bee57246d07af221e8fe82c853b3dc278c4fffca8852b463bcdc435a58273</citedby><cites>FETCH-LOGICAL-c4157-8b35bee57246d07af221e8fe82c853b3dc278c4fffca8852b463bcdc435a58273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Facr.22227$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Facr.22227$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24877201$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Juarez, M.</creatorcontrib><creatorcontrib>Toms, T. E.</creatorcontrib><creatorcontrib>Pablo, P.</creatorcontrib><creatorcontrib>Mitchell, S.</creatorcontrib><creatorcontrib>Bowman, S.</creatorcontrib><creatorcontrib>Nightingale, P.</creatorcontrib><creatorcontrib>Price, E. J.</creatorcontrib><creatorcontrib>Griffiths, B.</creatorcontrib><creatorcontrib>Hunter, J.</creatorcontrib><creatorcontrib>Gupta, M.</creatorcontrib><creatorcontrib>Bombardieri, M.</creatorcontrib><creatorcontrib>Sutcliffe, N.</creatorcontrib><creatorcontrib>Pitzalis, C.</creatorcontrib><creatorcontrib>Pease, C.</creatorcontrib><creatorcontrib>Andrews, J.</creatorcontrib><creatorcontrib>Emery, P.</creatorcontrib><creatorcontrib>Regan, M.</creatorcontrib><creatorcontrib>Giles, I.</creatorcontrib><creatorcontrib>Isenberg, D.</creatorcontrib><creatorcontrib>Moots, R.</creatorcontrib><creatorcontrib>Collins, K. S.</creatorcontrib><creatorcontrib>Ng, W. F.</creatorcontrib><creatorcontrib>Kitas, G. D.</creatorcontrib><creatorcontrib>UK Primary Sjögren’s Syndrome Registry</creatorcontrib><creatorcontrib>on behalf of the UK Primary Sjögren's Syndrome Registry</creatorcontrib><title>Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results</title><title>Arthritis care & research (2010)</title><addtitle>Arthritis Care Res (Hoboken)</addtitle><description>Objective
To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well‐characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.
Methods
Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.
Results
Primary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age‐ and sex‐matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.
Conclusion
Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age‐ and sex‐matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.</description><subject>Adult</subject><subject>Aged</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cohort Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension - diagnosis</subject><subject>Hypertension - epidemiology</subject><subject>Hypertriglyceridemia - diagnosis</subject><subject>Hypertriglyceridemia - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Registries</subject><subject>Risk Factors</subject><subject>Sjogren's Syndrome - diagnosis</subject><subject>Sjogren's Syndrome - epidemiology</subject><subject>SjöGren's Syndrome</subject><subject>United Kingdom - epidemiology</subject><issn>2151-464X</issn><issn>2151-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp9kc1O3DAURi0EAgSz4AWQd6WLgfgv8XRRCY1KW4EEGhjBznKcm8E0icFOqGbLQ_ECfbF6yDCCBdyFbekeHX_Sh9AeSQ5JktAjbfwhjZOtoW1KBBnyVMj11ZvfbKFBCHdJHEalZKNNtEW5zDKakG30NNa-sO5RB9NV2uOJDX_wiTat8wHbBl-7GuJp21t84W2t_Rxf3v17nnlovgR8OW8KH4lveNrYFgp8aptZ4erPWDyBmQ1tXE4gdFUbdtFGqasAg-W9g6YnP67Gv4Zn5z9_j4_PhoYTkQ1lzkQOIDLK0yLJdEkpAVmCpEYKlrPC0EwaXpal0VIKmvOU5aYwnAktJM3YDvree--7vIbCQNN6Xan7Pqpy2qr3m8beqpl7VFzQUZouBAdLgXcPHYRW1TYYqCrdgOuCIoIlo5gvZRH92qPGuxA8lKtvSKIWtalYm3qpLbL7b3OtyNeSInDUA39tBfOPTep4POmV_wEHOKXu</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Juarez, M.</creator><creator>Toms, T. E.</creator><creator>Pablo, P.</creator><creator>Mitchell, S.</creator><creator>Bowman, S.</creator><creator>Nightingale, P.</creator><creator>Price, E. J.</creator><creator>Griffiths, B.</creator><creator>Hunter, J.</creator><creator>Gupta, M.</creator><creator>Bombardieri, M.</creator><creator>Sutcliffe, N.</creator><creator>Pitzalis, C.</creator><creator>Pease, C.</creator><creator>Andrews, J.</creator><creator>Emery, P.</creator><creator>Regan, M.</creator><creator>Giles, I.</creator><creator>Isenberg, D.</creator><creator>Moots, R.</creator><creator>Collins, K. S.</creator><creator>Ng, W. F.</creator><creator>Kitas, G. D.</creator><general>Blackwell Publishing Ltd</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201405</creationdate><title>Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results</title><author>Juarez, M. ; Toms, T. E. ; Pablo, P. ; Mitchell, S. ; Bowman, S. ; Nightingale, P. ; Price, E. J. ; Griffiths, B. ; Hunter, J. ; Gupta, M. ; Bombardieri, M. ; Sutcliffe, N. ; Pitzalis, C. ; Pease, C. ; Andrews, J. ; Emery, P. ; Regan, M. ; Giles, I. ; Isenberg, D. ; Moots, R. ; Collins, K. S. ; Ng, W. F. ; Kitas, G. D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4157-8b35bee57246d07af221e8fe82c853b3dc278c4fffca8852b463bcdc435a58273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cardiovascular Diseases - diagnosis</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cohort Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension - diagnosis</topic><topic>Hypertension - epidemiology</topic><topic>Hypertriglyceridemia - diagnosis</topic><topic>Hypertriglyceridemia - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Registries</topic><topic>Risk Factors</topic><topic>Sjogren's Syndrome - diagnosis</topic><topic>Sjogren's Syndrome - epidemiology</topic><topic>SjöGren's Syndrome</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Juarez, M.</creatorcontrib><creatorcontrib>Toms, T. E.</creatorcontrib><creatorcontrib>Pablo, P.</creatorcontrib><creatorcontrib>Mitchell, S.</creatorcontrib><creatorcontrib>Bowman, S.</creatorcontrib><creatorcontrib>Nightingale, P.</creatorcontrib><creatorcontrib>Price, E. J.</creatorcontrib><creatorcontrib>Griffiths, B.</creatorcontrib><creatorcontrib>Hunter, J.</creatorcontrib><creatorcontrib>Gupta, M.</creatorcontrib><creatorcontrib>Bombardieri, M.</creatorcontrib><creatorcontrib>Sutcliffe, N.</creatorcontrib><creatorcontrib>Pitzalis, C.</creatorcontrib><creatorcontrib>Pease, C.</creatorcontrib><creatorcontrib>Andrews, J.</creatorcontrib><creatorcontrib>Emery, P.</creatorcontrib><creatorcontrib>Regan, M.</creatorcontrib><creatorcontrib>Giles, I.</creatorcontrib><creatorcontrib>Isenberg, D.</creatorcontrib><creatorcontrib>Moots, R.</creatorcontrib><creatorcontrib>Collins, K. S.</creatorcontrib><creatorcontrib>Ng, W. F.</creatorcontrib><creatorcontrib>Kitas, G. D.</creatorcontrib><creatorcontrib>UK Primary Sjögren’s Syndrome Registry</creatorcontrib><creatorcontrib>on behalf of the UK Primary Sjögren's Syndrome Registry</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arthritis care & research (2010)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Juarez, M.</au><au>Toms, T. E.</au><au>Pablo, P.</au><au>Mitchell, S.</au><au>Bowman, S.</au><au>Nightingale, P.</au><au>Price, E. J.</au><au>Griffiths, B.</au><au>Hunter, J.</au><au>Gupta, M.</au><au>Bombardieri, M.</au><au>Sutcliffe, N.</au><au>Pitzalis, C.</au><au>Pease, C.</au><au>Andrews, J.</au><au>Emery, P.</au><au>Regan, M.</au><au>Giles, I.</au><au>Isenberg, D.</au><au>Moots, R.</au><au>Collins, K. S.</au><au>Ng, W. F.</au><au>Kitas, G. D.</au><aucorp>UK Primary Sjögren’s Syndrome Registry</aucorp><aucorp>on behalf of the UK Primary Sjögren's Syndrome Registry</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results</atitle><jtitle>Arthritis care & research (2010)</jtitle><addtitle>Arthritis Care Res (Hoboken)</addtitle><date>2014-05</date><risdate>2014</risdate><volume>66</volume><issue>5</issue><spage>757</spage><epage>764</epage><pages>757-764</pages><issn>2151-464X</issn><eissn>2151-4658</eissn><abstract>Objective
To determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well‐characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.
Methods
Data on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.
Results
Primary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age‐ and sex‐matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.
Conclusion
Primary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age‐ and sex‐matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>24877201</pmid><doi>10.1002/acr.22227</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2151-464X |
| ispartof | Arthritis care & research (2010), 2014-05, Vol.66 (5), p.757-764 |
| issn | 2151-464X 2151-4658 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4529667 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Cardiovascular Diseases - diagnosis Cardiovascular Diseases - epidemiology Cohort Studies Female Humans Hypertension - diagnosis Hypertension - epidemiology Hypertriglyceridemia - diagnosis Hypertriglyceridemia - epidemiology Male Middle Aged Prospective Studies Registries Risk Factors Sjogren's Syndrome - diagnosis Sjogren's Syndrome - epidemiology SjöGren's Syndrome United Kingdom - epidemiology |
| title | Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T13%3A12%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiovascular%20Risk%20Factors%20in%20Women%20With%20Primary%20Sj%C3%B6gren's%20Syndrome:%20United%20Kingdom%20Primary%20Sj%C3%B6gren's%20Syndrome%20Registry%20Results&rft.jtitle=Arthritis%20care%20&%20research%20(2010)&rft.au=Juarez,%20M.&rft.aucorp=UK%20Primary%20Sj%C3%B6gren%E2%80%99s%20Syndrome%20Registry&rft.date=2014-05&rft.volume=66&rft.issue=5&rft.spage=757&rft.epage=764&rft.pages=757-764&rft.issn=2151-464X&rft.eissn=2151-4658&rft_id=info:doi/10.1002/acr.22227&rft_dat=%3Cproquest_pubme%3E1530957263%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1530957263&rft_id=info:pmid/24877201&rfr_iscdi=true |