Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification

Chromatin remodelling proteins are essential for different aspects of metazoan biology, yet functional details of why these proteins are important are lacking. Although it is possible to describe the biochemistry of how they remodel chromatin, their chromatin-binding profiles in cell lines, and gene...

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Veröffentlicht in:	Development (Cambridge) 2015-08, Vol.142 (15), p.2586-2597
Hauptverfasser:	O'Shaughnessy-Kirwan, Aoife, Signolet, Jason, Costello, Ita, Gharbi, Sarah, Hendrich, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blastocyst - physiology Cell Differentiation - physiology Cell Lineage - physiology Chromatin Assembly and Disassembly - genetics Crosses, Genetic DNA Helicases - metabolism DNA Primers - genetics Fluorescent Antibody Technique Gene Expression Regulation, Developmental - physiology In Situ Nick-End Labeling Metazoa Mice Mice, Inbred C57BL Multiplex Polymerase Chain Reaction Single-Cell Analysis Stem Cells and Regeneration
Online-Zugang:	Volltext
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