Functional Proteomics Identifies Acinus L as a Direct Insulin- and Amino Acid-Dependent Mammalian Target of Rapamycin Complex 1 (mTORC1) Substrate

The serine/threonine kinase mammalian target of rapamycin (mTOR) governs growth, metabolism, and aging in response to insulin and amino acids (aa), and is often activated in metabolic disorders and cancer. Much is known about the regulatory signaling network that encompasses mTOR, but surprisingly f...

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Veröffentlicht in:	Molecular & cellular proteomics 2015-08, Vol.14 (8), p.2042-2055
Hauptverfasser:	Schwarz, Jennifer Jasmin, Wiese, Heike, Tölle, Regine Charlotte, Zarei, Mostafa, Dengjel, Jörn, Warscheid, Bettina, Thedieck, Kathrin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Amino Acid Sequence Amino Acids - metabolism Gene Knockdown Techniques HeLa Cells Humans Insulin - metabolism Mechanistic Target of Rapamycin Complex 1 Molecular Sequence Data Multiprotein Complexes - metabolism Nuclear Proteins - chemistry Nuclear Proteins - metabolism Phosphoproteins - metabolism Phosphorylation Protein Interaction Mapping Proteome - metabolism Proteomics - methods Regulatory-Associated Protein of mTOR Substrate Specificity TOR Serine-Threonine Kinases - metabolism
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