Loss of MyD88 alters neuroinflammatory response and attenuates early Purkinje cell loss in a spinocerebellar ataxia type 6 mouse model

Spinocerebellar ataxia type 6 (SCA6) is dominantly inherited neurodegenerative disease, caused by an expansion of CAG repeat encoding a polyglutamine (PolyQ) tract in the Cav2.1 voltage-gated calcium channel. Its key pathological features include selective degeneration of the cerebellar Purkinje cel...

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Veröffentlicht in:	Human molecular genetics 2015-09, Vol.24 (17), p.4780-4791
Hauptverfasser:	Aikawa, Tomonori, Mogushi, Kaoru, Iijima-Tsutsui, Kumiko, Ishikawa, Kinya, Sakurai, Miyano, Tanaka, Hiroshi, Mizusawa, Hidehiro, Watase, Kei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Cerebellum - metabolism Cerebellum - pathology Cytokines - metabolism Disease Models, Animal Gene Deletion Gene Expression Gene Expression Profiling Humans Inflammation Mediators - metabolism Mice Microglia - metabolism Motor Activity Myeloid Differentiation Factor 88 - deficiency Myeloid Differentiation Factor 88 - genetics Purkinje Cells - metabolism RNA, Messenger - genetics Spinocerebellar Ataxias - genetics Spinocerebellar Ataxias - pathology
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