Pre-Clinical Evaluation of Fluorescent Deoxyglucose as a Topical Contrast Agent for the Detection of Barrett's-Associated Neoplasia during Confocal Imaging

The availability of confocal endomicroscopy motivates the development of optical contrast agents that can delineate the morphologic and metabolic features of gastrointestinal neoplasia. This study evaluates 2-NBDG, a fluorescent deoxyglucose, the uptake of which is associated with increased metaboli...

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Veröffentlicht in:	Technology in cancer research & treatment 2011-10, Vol.10 (5), p.431-441
Hauptverfasser:	Thekkek, N., Maru, D. M., Polydorides, A. D., Bhutani, M. S., Anandasabapathy, S., Richards-Kortum, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Chloro-7-nitrobenzofurazan - analogs & derivatives Adenocarcinoma - diagnosis Adenocarcinoma - pathology Administration, Topical Algorithms Area Under Curve Barrett Esophagus - diagnosis Barrett Esophagus - pathology Biopsy Contrast Media Deoxyglucose - analogs & derivatives Drug Evaluation, Preclinical Esophageal Neoplasms - diagnosis Esophageal Neoplasms - pathology Esophagoscopy Esophagus - pathology Fluorescent Dyes Goblet Cells - pathology Humans Microscopy, Confocal ROC Curve
Online-Zugang:	Volltext
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