Evaluation of acute effects of melatonin on ethanol drinking in ethanol naïve rats
The objective was to evaluate the acute effect of melatonin on ethanol drinking in ethanol naïve rats and to determine the specificity of the effect of melatonin on ethanol intake as compared to an intake of plain tap water or sugar water. A total of three experiments (2 weeks duration each) using d...
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| Veröffentlicht in: | Indian journal of pharmacology 2015-07, Vol.47 (4), p.383-387 |
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| creator | Rather, Zahoor Ahmad Chowta, Mukta N Bolumbu, Ganaraja Rakesh, K B |
| description | The objective was to evaluate the acute effect of melatonin on ethanol drinking in ethanol naïve rats and to determine the specificity of the effect of melatonin on ethanol intake as compared to an intake of plain tap water or sugar water.
A total of three experiments (2 weeks duration each) using different drinking solutions (ethanol, plain tap water, sugar water) was conducted in individually housed male wistar rats of 5 weeks age. Each animal had access to bottles containing drinking solutions for 2 h a day. In each experiment, on day 1, day 2, day 4, day 5, day 8, day 9, day 11, day 12 rats received drinking solutions. Each individual rat received single doses of saline, melatonin (50 mg and 100 mg/kg), and naltrexone on day 2, 5, 9, and 12, 1-h before receiving drinking solution. The order of drug administration is permuted such a way that each animal received the drugs in a different order in different experiments.
Melatonin has significantly decreased ethanol consumption by the rats and effect is dose-dependent. Naltrexone also has caused a significant reduction in the ethanol consumption. The maximum reduction in ethanol consumption was seen with melatonin 100 mg/kg dose compared to melatonin 50 mg/kg and naltrexone. There was no statistically significant effect of melatonin on plain water and sugar solution intake.
Melatonin decreases ethanol consumption in ethanol naïve rats. The effect of melatonin is similar to naltrexone affecting selectively ethanol consumption, but not plain water and sugar water consumption. |
| doi_str_mv | 10.4103/0253-7613.161259 |
| format | Article |
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A total of three experiments (2 weeks duration each) using different drinking solutions (ethanol, plain tap water, sugar water) was conducted in individually housed male wistar rats of 5 weeks age. Each animal had access to bottles containing drinking solutions for 2 h a day. In each experiment, on day 1, day 2, day 4, day 5, day 8, day 9, day 11, day 12 rats received drinking solutions. Each individual rat received single doses of saline, melatonin (50 mg and 100 mg/kg), and naltrexone on day 2, 5, 9, and 12, 1-h before receiving drinking solution. The order of drug administration is permuted such a way that each animal received the drugs in a different order in different experiments.
Melatonin has significantly decreased ethanol consumption by the rats and effect is dose-dependent. Naltrexone also has caused a significant reduction in the ethanol consumption. The maximum reduction in ethanol consumption was seen with melatonin 100 mg/kg dose compared to melatonin 50 mg/kg and naltrexone. There was no statistically significant effect of melatonin on plain water and sugar solution intake.
Melatonin decreases ethanol consumption in ethanol naïve rats. The effect of melatonin is similar to naltrexone affecting selectively ethanol consumption, but not plain water and sugar water consumption.</description><identifier>ISSN: 0253-7613</identifier><identifier>EISSN: 1998-3751</identifier><identifier>DOI: 10.4103/0253-7613.161259</identifier><identifier>PMID: 26288469</identifier><language>eng</language><publisher>India: Medknow Publications and Media Pvt. Ltd</publisher><subject>Alcohol Drinking - prevention & control ; Animal behavior ; Animals ; Dose-Response Relationship, Drug ; Ethanol ; Ethanol - administration & dosage ; Health aspects ; Male ; Melatonin ; Melatonin - administration & dosage ; Melatonin - pharmacology ; Naltrexone - pharmacology ; Narcotic Antagonists - pharmacology ; Pharmacology ; Rats ; Rats, Wistar ; Rodents</subject><ispartof>Indian journal of pharmacology, 2015-07, Vol.47 (4), p.383-387</ispartof><rights>COPYRIGHT 2015 Medknow Publications and Media Pvt. Ltd.</rights><rights>Copyright Medknow Publications & Media Pvt Ltd Aug 2015</rights><rights>Copyright: © Indian Journal of Pharmacology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-140c37ec2b9af9ed81b03bb073a5f7480a7cc9484bab842ac93f7e9ebbeaddf43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527058/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4527058/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26288469$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rather, Zahoor Ahmad</creatorcontrib><creatorcontrib>Chowta, Mukta N</creatorcontrib><creatorcontrib>Bolumbu, Ganaraja</creatorcontrib><creatorcontrib>Rakesh, K B</creatorcontrib><title>Evaluation of acute effects of melatonin on ethanol drinking in ethanol naïve rats</title><title>Indian journal of pharmacology</title><addtitle>Indian J Pharmacol</addtitle><description>The objective was to evaluate the acute effect of melatonin on ethanol drinking in ethanol naïve rats and to determine the specificity of the effect of melatonin on ethanol intake as compared to an intake of plain tap water or sugar water.
A total of three experiments (2 weeks duration each) using different drinking solutions (ethanol, plain tap water, sugar water) was conducted in individually housed male wistar rats of 5 weeks age. Each animal had access to bottles containing drinking solutions for 2 h a day. In each experiment, on day 1, day 2, day 4, day 5, day 8, day 9, day 11, day 12 rats received drinking solutions. Each individual rat received single doses of saline, melatonin (50 mg and 100 mg/kg), and naltrexone on day 2, 5, 9, and 12, 1-h before receiving drinking solution. The order of drug administration is permuted such a way that each animal received the drugs in a different order in different experiments.
Melatonin has significantly decreased ethanol consumption by the rats and effect is dose-dependent. Naltrexone also has caused a significant reduction in the ethanol consumption. The maximum reduction in ethanol consumption was seen with melatonin 100 mg/kg dose compared to melatonin 50 mg/kg and naltrexone. There was no statistically significant effect of melatonin on plain water and sugar solution intake.
Melatonin decreases ethanol consumption in ethanol naïve rats. The effect of melatonin is similar to naltrexone affecting selectively ethanol consumption, but not plain water and sugar water consumption.</description><subject>Alcohol Drinking - prevention & control</subject><subject>Animal behavior</subject><subject>Animals</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol</subject><subject>Ethanol - administration & dosage</subject><subject>Health aspects</subject><subject>Male</subject><subject>Melatonin</subject><subject>Melatonin - administration & dosage</subject><subject>Melatonin - pharmacology</subject><subject>Naltrexone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><issn>0253-7613</issn><issn>1998-3751</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptks1u1DAUhS1ERYfCnhWKxIZNpv6N7Q1SVbWAVKkLYG05zvXUJbFLnIzEU_EQvFgdTZnSauSF5Xu_c2xfHYTeEbzmBLNTTAWrZUPYmjSECv0CrYjWqmZSkJdotW8fo9c53-Jy5rp5hY5pQ5XijV6hbxdb2892CilWyVfWzRNU4D24KS-FAXo7pRhKN1Yw3diY-qobQ_wZ4qYKj7Vo__7ZQjXaKb9BR972Gd4-7Cfox-XF9_Mv9dX156_nZ1e1E1RPNeHYMQmOttp6DZ0iLWZtiyWzwkuusJXOaa54a1vFqXWaeQka2hZs13nOTtCnne_d3A7QOYjTaHtzN4bBjr9NssE87cRwYzZpa7igEgtVDD4-GIzp1wx5MkPIDvreRkhzNqRQkmGsREE_PENv0zzG8r2F4pJxLsgjtbE9mBB9Kve6xdSccUqVFFouVH2A2kCE8sgUwYdSfsKvD_BldTAEd1CAdwI3ppxH8PuZEGyW4JglGWZJhtkFp0je_z_LveBfUtg9tMG-Iw</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Rather, Zahoor Ahmad</creator><creator>Chowta, Mukta N</creator><creator>Bolumbu, Ganaraja</creator><creator>Rakesh, K B</creator><general>Medknow Publications and Media Pvt. 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A total of three experiments (2 weeks duration each) using different drinking solutions (ethanol, plain tap water, sugar water) was conducted in individually housed male wistar rats of 5 weeks age. Each animal had access to bottles containing drinking solutions for 2 h a day. In each experiment, on day 1, day 2, day 4, day 5, day 8, day 9, day 11, day 12 rats received drinking solutions. Each individual rat received single doses of saline, melatonin (50 mg and 100 mg/kg), and naltrexone on day 2, 5, 9, and 12, 1-h before receiving drinking solution. The order of drug administration is permuted such a way that each animal received the drugs in a different order in different experiments.
Melatonin has significantly decreased ethanol consumption by the rats and effect is dose-dependent. Naltrexone also has caused a significant reduction in the ethanol consumption. The maximum reduction in ethanol consumption was seen with melatonin 100 mg/kg dose compared to melatonin 50 mg/kg and naltrexone. There was no statistically significant effect of melatonin on plain water and sugar solution intake.
Melatonin decreases ethanol consumption in ethanol naïve rats. The effect of melatonin is similar to naltrexone affecting selectively ethanol consumption, but not plain water and sugar water consumption.</abstract><cop>India</cop><pub>Medknow Publications and Media Pvt. Ltd</pub><pmid>26288469</pmid><doi>10.4103/0253-7613.161259</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0253-7613 |
| ispartof | Indian journal of pharmacology, 2015-07, Vol.47 (4), p.383-387 |
| issn | 0253-7613 1998-3751 |
| language | eng |
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| source | MEDLINE; PubMed Central; Free Full-Text Journals in Chemistry; EZB Electronic Journals Library; PubMed Central Open Access |
| subjects | Alcohol Drinking - prevention & control Animal behavior Animals Dose-Response Relationship, Drug Ethanol Ethanol - administration & dosage Health aspects Male Melatonin Melatonin - administration & dosage Melatonin - pharmacology Naltrexone - pharmacology Narcotic Antagonists - pharmacology Pharmacology Rats Rats, Wistar Rodents |
| title | Evaluation of acute effects of melatonin on ethanol drinking in ethanol naïve rats |
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