Endometrial tubal metaplasia in a young puerperal woman after breast cancer
Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre and post-menopausal women. Previous studies have suggested an increased prevalence of endometrial diseases after treatment with tamoxifen. The authors report a case of 38-year-old woman with d...
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| Veröffentlicht in: | International journal of clinical and experimental pathology 2015-01, Vol.8 (6), p.7610-7613 |
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| creator | Di Benedetto, Luisa Giovanale, Valentina Caserta, Donatella |
| description | Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre and post-menopausal women. Previous studies have suggested an increased prevalence of endometrial diseases after treatment with tamoxifen.
The authors report a case of 38-year-old woman with diagnosis of endometrial polyp and tubal metaplasia, during puerperium and after micropapillary ductal breast cancer surgery, 5 years of tamoxifen treatment, spontaneous pregnancy without complications and full-term vaginal delivery.
Tamoxifen is a safe and reliable treatment of breast cancer, but data suggest an association with endometrial polyps, hyperplasia, metaplasia and carcinoma. One of the most common types of endometrial metaplasia is ciliated tubal metaplasia. It is generally known that endometrial tubal metaplasia is a benign disease. However studies propose endometrial tubal metaplasia to be a potential premalignant endometrial lesion and its association with endometrial hyperplasia and well-differentiated endometrioid carcinoma. We propose close monitoring of patients taking tamoxifen and prompt evaluation of any uterine bleeding or pelvic complaint or abnormal TVUS images. |
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The authors report a case of 38-year-old woman with diagnosis of endometrial polyp and tubal metaplasia, during puerperium and after micropapillary ductal breast cancer surgery, 5 years of tamoxifen treatment, spontaneous pregnancy without complications and full-term vaginal delivery.
Tamoxifen is a safe and reliable treatment of breast cancer, but data suggest an association with endometrial polyps, hyperplasia, metaplasia and carcinoma. One of the most common types of endometrial metaplasia is ciliated tubal metaplasia. It is generally known that endometrial tubal metaplasia is a benign disease. However studies propose endometrial tubal metaplasia to be a potential premalignant endometrial lesion and its association with endometrial hyperplasia and well-differentiated endometrioid carcinoma. We propose close monitoring of patients taking tamoxifen and prompt evaluation of any uterine bleeding or pelvic complaint or abnormal TVUS images.</description><identifier>EISSN: 1936-2625</identifier><identifier>PMID: 26261678</identifier><language>eng</language><publisher>United States: e-Century Publishing Corporation</publisher><subject>Adult ; Antineoplastic Agents, Hormonal - adverse effects ; Breast Neoplasms - drug therapy ; Breast Neoplasms - pathology ; Breast Neoplasms - surgery ; Case Report ; Chemotherapy, Adjuvant ; Endometrial Hyperplasia - chemically induced ; Endometrial Hyperplasia - pathology ; Endometrial Hyperplasia - surgery ; Endometrium - drug effects ; Endometrium - pathology ; Endometrium - surgery ; Fallopian Tube Diseases - chemically induced ; Fallopian Tube Diseases - pathology ; Fallopian Tube Diseases - surgery ; Fallopian Tubes - drug effects ; Fallopian Tubes - pathology ; Fallopian Tubes - surgery ; Female ; Humans ; Hysteroscopy ; Mastectomy ; Metaplasia ; Polyps - chemically induced ; Polyps - pathology ; Polyps - surgery ; Postpartum Period ; Pregnancy ; Tamoxifen - adverse effects ; Time Factors ; Treatment Outcome</subject><ispartof>International journal of clinical and experimental pathology, 2015-01, Vol.8 (6), p.7610-7613</ispartof><rights>IJCEP Copyright © 2015 2015</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526012/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526012/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26261678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Benedetto, Luisa</creatorcontrib><creatorcontrib>Giovanale, Valentina</creatorcontrib><creatorcontrib>Caserta, Donatella</creatorcontrib><title>Endometrial tubal metaplasia in a young puerperal woman after breast cancer</title><title>International journal of clinical and experimental pathology</title><addtitle>Int J Clin Exp Pathol</addtitle><description>Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre and post-menopausal women. Previous studies have suggested an increased prevalence of endometrial diseases after treatment with tamoxifen.
The authors report a case of 38-year-old woman with diagnosis of endometrial polyp and tubal metaplasia, during puerperium and after micropapillary ductal breast cancer surgery, 5 years of tamoxifen treatment, spontaneous pregnancy without complications and full-term vaginal delivery.
Tamoxifen is a safe and reliable treatment of breast cancer, but data suggest an association with endometrial polyps, hyperplasia, metaplasia and carcinoma. One of the most common types of endometrial metaplasia is ciliated tubal metaplasia. It is generally known that endometrial tubal metaplasia is a benign disease. However studies propose endometrial tubal metaplasia to be a potential premalignant endometrial lesion and its association with endometrial hyperplasia and well-differentiated endometrioid carcinoma. We propose close monitoring of patients taking tamoxifen and prompt evaluation of any uterine bleeding or pelvic complaint or abnormal TVUS images.</description><subject>Adult</subject><subject>Antineoplastic Agents, Hormonal - adverse effects</subject><subject>Breast Neoplasms - drug therapy</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - surgery</subject><subject>Case Report</subject><subject>Chemotherapy, Adjuvant</subject><subject>Endometrial Hyperplasia - chemically induced</subject><subject>Endometrial Hyperplasia - pathology</subject><subject>Endometrial Hyperplasia - surgery</subject><subject>Endometrium - drug effects</subject><subject>Endometrium - pathology</subject><subject>Endometrium - surgery</subject><subject>Fallopian Tube Diseases - chemically induced</subject><subject>Fallopian Tube Diseases - pathology</subject><subject>Fallopian Tube Diseases - surgery</subject><subject>Fallopian Tubes - drug effects</subject><subject>Fallopian Tubes - pathology</subject><subject>Fallopian Tubes - surgery</subject><subject>Female</subject><subject>Humans</subject><subject>Hysteroscopy</subject><subject>Mastectomy</subject><subject>Metaplasia</subject><subject>Polyps - chemically induced</subject><subject>Polyps - pathology</subject><subject>Polyps - surgery</subject><subject>Postpartum Period</subject><subject>Pregnancy</subject><subject>Tamoxifen - adverse effects</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>1936-2625</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUE1LxDAQDYK46-pfkBy9FPLVpL0Isqy6uOBFz2U6TddK29QkVfbfG3AVvcww7828N7wTsuSl1JnQIl-Q8xDeGNNcKHZGFgnTXJtiSR43Y-MGG30HPY1znWqaYOohdEC7kQI9uHnc02m2frI-8Z9ugIS30XpaewshUoQRrb8gpy30wV4e-4q83G2e1w_Z7ul-u77dZZPQOma8MchyLEWdl63RUuYN2rJAVKAQOENsZNHmoFSpUDHTcotoaimxaBvWFHJFbr51p7kebDoeY_qrmnw3gD9UDrrqPzN2r9XefVQqF5pxkQSujwLevc82xGroAtq-h9G6OVTcMGl4XgqZVq_-ev2a_CQovwD0nW5B</recordid><startdate>20150101</startdate><enddate>20150101</enddate><creator>Di Benedetto, Luisa</creator><creator>Giovanale, Valentina</creator><creator>Caserta, Donatella</creator><general>e-Century Publishing Corporation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150101</creationdate><title>Endometrial tubal metaplasia in a young puerperal woman after breast cancer</title><author>Di Benedetto, Luisa ; Giovanale, Valentina ; Caserta, Donatella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-1d7c05c92b59f76335dce98cc4a4ca10ccd38f5a4494c407f1ecc7b33c8fd0d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Antineoplastic Agents, Hormonal - adverse effects</topic><topic>Breast Neoplasms - drug therapy</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - surgery</topic><topic>Case Report</topic><topic>Chemotherapy, Adjuvant</topic><topic>Endometrial Hyperplasia - chemically induced</topic><topic>Endometrial Hyperplasia - pathology</topic><topic>Endometrial Hyperplasia - surgery</topic><topic>Endometrium - drug effects</topic><topic>Endometrium - pathology</topic><topic>Endometrium - surgery</topic><topic>Fallopian Tube Diseases - chemically induced</topic><topic>Fallopian Tube Diseases - pathology</topic><topic>Fallopian Tube Diseases - surgery</topic><topic>Fallopian Tubes - drug effects</topic><topic>Fallopian Tubes - pathology</topic><topic>Fallopian Tubes - surgery</topic><topic>Female</topic><topic>Humans</topic><topic>Hysteroscopy</topic><topic>Mastectomy</topic><topic>Metaplasia</topic><topic>Polyps - chemically induced</topic><topic>Polyps - pathology</topic><topic>Polyps - surgery</topic><topic>Postpartum Period</topic><topic>Pregnancy</topic><topic>Tamoxifen - adverse effects</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Di Benedetto, Luisa</creatorcontrib><creatorcontrib>Giovanale, Valentina</creatorcontrib><creatorcontrib>Caserta, Donatella</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of clinical and experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Benedetto, Luisa</au><au>Giovanale, Valentina</au><au>Caserta, Donatella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endometrial tubal metaplasia in a young puerperal woman after breast cancer</atitle><jtitle>International journal of clinical and experimental pathology</jtitle><addtitle>Int J Clin Exp Pathol</addtitle><date>2015-01-01</date><risdate>2015</risdate><volume>8</volume><issue>6</issue><spage>7610</spage><epage>7613</epage><pages>7610-7613</pages><eissn>1936-2625</eissn><abstract>Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre and post-menopausal women. Previous studies have suggested an increased prevalence of endometrial diseases after treatment with tamoxifen.
The authors report a case of 38-year-old woman with diagnosis of endometrial polyp and tubal metaplasia, during puerperium and after micropapillary ductal breast cancer surgery, 5 years of tamoxifen treatment, spontaneous pregnancy without complications and full-term vaginal delivery.
Tamoxifen is a safe and reliable treatment of breast cancer, but data suggest an association with endometrial polyps, hyperplasia, metaplasia and carcinoma. One of the most common types of endometrial metaplasia is ciliated tubal metaplasia. It is generally known that endometrial tubal metaplasia is a benign disease. However studies propose endometrial tubal metaplasia to be a potential premalignant endometrial lesion and its association with endometrial hyperplasia and well-differentiated endometrioid carcinoma. We propose close monitoring of patients taking tamoxifen and prompt evaluation of any uterine bleeding or pelvic complaint or abnormal TVUS images.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>26261678</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Antineoplastic Agents, Hormonal - adverse effects Breast Neoplasms - drug therapy Breast Neoplasms - pathology Breast Neoplasms - surgery Case Report Chemotherapy, Adjuvant Endometrial Hyperplasia - chemically induced Endometrial Hyperplasia - pathology Endometrial Hyperplasia - surgery Endometrium - drug effects Endometrium - pathology Endometrium - surgery Fallopian Tube Diseases - chemically induced Fallopian Tube Diseases - pathology Fallopian Tube Diseases - surgery Fallopian Tubes - drug effects Fallopian Tubes - pathology Fallopian Tubes - surgery Female Humans Hysteroscopy Mastectomy Metaplasia Polyps - chemically induced Polyps - pathology Polyps - surgery Postpartum Period Pregnancy Tamoxifen - adverse effects Time Factors Treatment Outcome |
| title | Endometrial tubal metaplasia in a young puerperal woman after breast cancer |
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