Protective Effects of Kaempferol against Myocardial Ischemia/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3β

Objective. This study aimed to evaluate the protective effect of kaempferol against myocardial ischemia/reperfusion (I/R) injury in rats. Method. Left ventricular developed pressure (LVDP) and its maximum up/down rate (±dp/dtmax) were recorded as myocardial function. Infarct size was detected with 2...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oxidative medicine and cellular longevity 2015-01, Vol.2015 (2015), p.1-8
Hauptverfasser:	Zheng, Qiusheng, Wang, Wenjuan, Han, Jichun, Ren, Huanhuan, Zhou, Mingjie, Wang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants Apoptosis Apoptosis - drug effects Caspase 3 - metabolism Cytochrome c Cytochromes c - metabolism Enzyme-linked immunosorbent assay Enzymes Glutathione - metabolism Glycogen Glycogen Synthase Kinase 3 - antagonists & inhibitors Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Heart - drug effects In Vitro Techniques Kaempferols - pharmacology Kaempferols - therapeutic use Male Myocardial Reperfusion Injury - prevention & control Myocardium - metabolism Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Oxidative Stress - drug effects Phosphorylation - drug effects Protective Agents - pharmacology Protective Agents - therapeutic use Rats Rats, Sprague-Dawley Superoxide Superoxide Dismutase - metabolism Synthesis Thiadiazoles - pharmacology Tumor necrosis factor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!