MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex

MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that MCM8-9 is required for DNA resection by MRN (MRE11-RAD50-NBS1) at DSBs to generate ssDNA. MCM8-9 interacts with MRN and is required for the nuclease activity and stable as...

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Veröffentlicht in:	Nature communications 2015-07, Vol.6 (1), p.7744-7744, Article 7744
Hauptverfasser:	Lee, Kyung Yong, Im, Jun-Sub, Shibata, Etsuko, Park, Jonghoon, Handa, Naofumi, Kowalczykowski, Stephen C., Dutta, Anindya
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 13/89 14/63 38/1 631/337/1427/2122 631/337/1427/2190 631/80/86 82/80 82/83 Acid Anhydride Hydrolases Animals ATP-Binding Cassette Transporters - metabolism Cancer Carrier Proteins - metabolism Cell cycle Cell Cycle Proteins - metabolism Chemotherapy Chromatin Immunoprecipitation DNA Breaks, Double-Stranded DNA Damage DNA Repair DNA Repair Enzymes - metabolism DNA, Single-Stranded DNA-Binding Proteins - metabolism Enzymes Epigenetics Genomes HEK293 Cells HeLa Cells Humanities and Social Sciences Humans Localization Mice Minichromosome Maintenance Proteins - metabolism MRE11 Homologue Protein multidisciplinary Mutation Nuclear Proteins - metabolism Ovaries Proteins Recombinational DNA Repair Science Science (multidisciplinary) Tumor Suppressor Proteins - metabolism Xenopus Xenopus Proteins - metabolism Yeast
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