The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

The transcriptional regulation of peroxisome proliferator-activated receptor (PPAR) α by post-translational modification, such as ubiquitin, has not been described. We report here for the first time an ubiquitin ligase (muscle ring finger-1/MuRF1) that inhibits fatty acid oxidation by inhibiting PPA...

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Veröffentlicht in:	Molecular and cellular endocrinology 2015-09, Vol.413, p.36-48
Hauptverfasser:	Rodríguez, Jessica E., Liao, Jie-Ying, He, Jun, Schisler, Jonathan C., Newgard, Christopher B., Drujan, Doreen, Glass, David J., Frederick, C. Brandon, Yoder, Bryan C., Lalush, David S., Patterson, Cam, Willis, Monte S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus - genetics Animals beta oxidation Cardiac metabolism Cardiomyocyte cardiomyocytes Cell Nucleus - genetics Cell Nucleus - metabolism Cell Nucleus - pathology Fatty acid metabolism heart failure Heart Failure - genetics Heart Failure - metabolism Heart Failure - pathology Mice Mice, Knockout Monoubiquitination Muscle Proteins - genetics Muscle Proteins - metabolism Muscle ring finger-1 muscles Myocardium - metabolism Myocardium - pathology Peroxisome proliferator-activated receptor α peroxisome proliferator-activated receptors physiological transport PPAR alpha - genetics PPAR alpha - metabolism proteasome endopeptidase complex transcription (genetics) Tripartite Motif Proteins ubiquitin ubiquitin-protein ligase Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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