Systemic moxifloxacin vs amoxicillin/metronidazole adjunct to non-surgical treatment in generalized aggressive periodontitis
The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin and metronidazole, combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in a 6-month follow-up. A total of 39 sys...
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| Veröffentlicht in: | Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2015-07, Vol.20 (4), p.e441-e449 |
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| container_title | Medicina oral, patología oral y cirugía bucal |
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| creator | Guzeldemir-Akcakanat, Esra Gurgan, Cem-Abdulkadir |
| description | The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin and metronidazole, combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in a 6-month follow-up.
A total of 39 systemically healthy patients with GAgP were evaluated in this randomized clinical trial. Periodontal parameters were recorded at the baseline during the 1st, 3rd and 6th month. Patients received either 400 mg of moxifloxacin per os once daily or 500 mg of metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.
No significant differences between groups were found in any parameters at the baseline. Both groups led to a statistically significant decrease in all clinical periodontal parameters compared to the baseline (PI; p |
| doi_str_mv | 10.4317/medoral.20552 |
| format | Article |
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A total of 39 systemically healthy patients with GAgP were evaluated in this randomized clinical trial. Periodontal parameters were recorded at the baseline during the 1st, 3rd and 6th month. Patients received either 400 mg of moxifloxacin per os once daily or 500 mg of metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.
No significant differences between groups were found in any parameters at the baseline. Both groups led to a statistically significant decrease in all clinical periodontal parameters compared to the baseline (PI; p<0.001 and GI, PD, BOP, CAL, p<0.01). There were no differences between the 1st and 3rd months or the 3rd and 6th months for clinical parameters in the groups. Also, no intergroup difference was observed in any parameters at any time, except the gingival index at 6th months.
Systemic administration of moxifloxacin as an adjunct to non-surgical treatment significantly improves clinical outcomes and provides comparable clinical improvement with less adverse events to that of combination of amoxicillin and metronidazole in the treatment of GAgP.</description><identifier>ISSN: 1698-6946</identifier><identifier>ISSN: 1698-4447</identifier><identifier>EISSN: 1698-6946</identifier><identifier>DOI: 10.4317/medoral.20552</identifier><identifier>PMID: 26034931</identifier><language>eng</language><publisher>Spain: Medicina Oral S.L</publisher><subject>Adult ; Aggressive Periodontitis - drug therapy ; Amoxicillin - administration & dosage ; Anti-Infective Agents - administration & dosage ; Dentistry ; Drug Therapy, Combination ; Female ; Fluoroquinolones - administration & dosage ; Follow-Up Studies ; Humans ; Male ; Metronidazole - administration & dosage ; Moxifloxacin ; Young Adult</subject><ispartof>Medicina oral, patología oral y cirugía bucal, 2015-07, Vol.20 (4), p.e441-e449</ispartof><rights>Copyright: © 2015 Medicina Oral S.L. 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-af77ae6a35a34c1e0eff3c48dc67f5b03aa0c396365a0ebea8bd080afedbacbe3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523257/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4523257/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26034931$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guzeldemir-Akcakanat, Esra</creatorcontrib><creatorcontrib>Gurgan, Cem-Abdulkadir</creatorcontrib><title>Systemic moxifloxacin vs amoxicillin/metronidazole adjunct to non-surgical treatment in generalized aggressive periodontitis</title><title>Medicina oral, patología oral y cirugía bucal</title><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><description>The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin and metronidazole, combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in a 6-month follow-up.
A total of 39 systemically healthy patients with GAgP were evaluated in this randomized clinical trial. Periodontal parameters were recorded at the baseline during the 1st, 3rd and 6th month. Patients received either 400 mg of moxifloxacin per os once daily or 500 mg of metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.
No significant differences between groups were found in any parameters at the baseline. Both groups led to a statistically significant decrease in all clinical periodontal parameters compared to the baseline (PI; p<0.001 and GI, PD, BOP, CAL, p<0.01). There were no differences between the 1st and 3rd months or the 3rd and 6th months for clinical parameters in the groups. Also, no intergroup difference was observed in any parameters at any time, except the gingival index at 6th months.
Systemic administration of moxifloxacin as an adjunct to non-surgical treatment significantly improves clinical outcomes and provides comparable clinical improvement with less adverse events to that of combination of amoxicillin and metronidazole in the treatment of GAgP.</description><subject>Adult</subject><subject>Aggressive Periodontitis - drug therapy</subject><subject>Amoxicillin - administration & dosage</subject><subject>Anti-Infective Agents - administration & dosage</subject><subject>Dentistry</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>Fluoroquinolones - administration & dosage</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Metronidazole - administration & dosage</subject><subject>Moxifloxacin</subject><subject>Young Adult</subject><issn>1698-6946</issn><issn>1698-4447</issn><issn>1698-6946</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1P3TAQtFAR38dekY-9hDp24iQXJIQoVELiAJytjbNJjRz7YTtPgPrja-AVwWlXu6OZ0Qwh30t2Uomy-Tnj4APYE87qmm-RvVJ2bSG7Sn77tO-S_RgfGBNN2cgdssslE1Unyj3y9_Y5JpyNprN_MqP1T6CNo-tI4fWgjbXGZZEUvDMDvHiLFIaHxelEk6fOuyIuYTIaLE0BIc3oEs0MEzrMvswLDhSmKWCMZo10hcH4wbtkkomHZHsEG_FoMw_I_a-Lu_Or4vrm8vf52XWhRdukAsamAZQgahCVLpHhOApdtYOWzVj3TAAwLTopZA0Me4S2H1jLYMShB92jOCCn77yrpc956WwxW1OrYGYIz8qDUV8_zvxRk1-rquaC100m-LEhCP5xwZjUbKJGa8GhX6LKQXPeccbbDC3eoTr4GAOOHzIlU6-NqU1j6q2xjD_-7O0D_b8i8Q_E-Jra</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Guzeldemir-Akcakanat, Esra</creator><creator>Gurgan, Cem-Abdulkadir</creator><general>Medicina Oral S.L</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150701</creationdate><title>Systemic moxifloxacin vs amoxicillin/metronidazole adjunct to non-surgical treatment in generalized aggressive periodontitis</title><author>Guzeldemir-Akcakanat, Esra ; Gurgan, Cem-Abdulkadir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-af77ae6a35a34c1e0eff3c48dc67f5b03aa0c396365a0ebea8bd080afedbacbe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Aggressive Periodontitis - drug therapy</topic><topic>Amoxicillin - administration & dosage</topic><topic>Anti-Infective Agents - administration & dosage</topic><topic>Dentistry</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>Fluoroquinolones - administration & dosage</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Metronidazole - administration & dosage</topic><topic>Moxifloxacin</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guzeldemir-Akcakanat, Esra</creatorcontrib><creatorcontrib>Gurgan, Cem-Abdulkadir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guzeldemir-Akcakanat, Esra</au><au>Gurgan, Cem-Abdulkadir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systemic moxifloxacin vs amoxicillin/metronidazole adjunct to non-surgical treatment in generalized aggressive periodontitis</atitle><jtitle>Medicina oral, patología oral y cirugía bucal</jtitle><addtitle>Med Oral Patol Oral Cir Bucal</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>20</volume><issue>4</issue><spage>e441</spage><epage>e449</epage><pages>e441-e449</pages><issn>1698-6946</issn><issn>1698-4447</issn><eissn>1698-6946</eissn><abstract>The objective of this randomized clinical study was to evaluate the effect of systemic administration of moxifloxacin compared to amoxicillin and metronidazole, combined with non-surgical treatment in patients with generalized aggressive periodontitis (GAgP) in a 6-month follow-up.
A total of 39 systemically healthy patients with GAgP were evaluated in this randomized clinical trial. Periodontal parameters were recorded at the baseline during the 1st, 3rd and 6th month. Patients received either 400 mg of moxifloxacin per os once daily or 500 mg of metronidazole and 500 mg amoxicillin per os three times daily for 7 days consecutively.
No significant differences between groups were found in any parameters at the baseline. Both groups led to a statistically significant decrease in all clinical periodontal parameters compared to the baseline (PI; p<0.001 and GI, PD, BOP, CAL, p<0.01). There were no differences between the 1st and 3rd months or the 3rd and 6th months for clinical parameters in the groups. Also, no intergroup difference was observed in any parameters at any time, except the gingival index at 6th months.
Systemic administration of moxifloxacin as an adjunct to non-surgical treatment significantly improves clinical outcomes and provides comparable clinical improvement with less adverse events to that of combination of amoxicillin and metronidazole in the treatment of GAgP.</abstract><cop>Spain</cop><pub>Medicina Oral S.L</pub><pmid>26034931</pmid><doi>10.4317/medoral.20552</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1698-6946 |
| ispartof | Medicina oral, patología oral y cirugía bucal, 2015-07, Vol.20 (4), p.e441-e449 |
| issn | 1698-6946 1698-4447 1698-6946 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4523257 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; PubMed Central Open Access |
| subjects | Adult Aggressive Periodontitis - drug therapy Amoxicillin - administration & dosage Anti-Infective Agents - administration & dosage Dentistry Drug Therapy, Combination Female Fluoroquinolones - administration & dosage Follow-Up Studies Humans Male Metronidazole - administration & dosage Moxifloxacin Young Adult |
| title | Systemic moxifloxacin vs amoxicillin/metronidazole adjunct to non-surgical treatment in generalized aggressive periodontitis |
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