A phase II study of RO4929097 in metastatic colorectal cancer

Abstract Background The Notch signalling pathway is activated in a variety of malignancies and has been implicated in colorectal cancer progression. One of the first steps in the Notch pathway activation is mediated by γ-secretase, a proteolytic enzyme which produces an activated intracellular Notch...

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Veröffentlicht in:	European journal of cancer (1990) 2012-05, Vol.48 (7), p.997-1003
Hauptverfasser:	Strosberg, Jonathan R, Yeatman, Timothy, Weber, Jill, Coppola, Domenico, Schell, Michael J, Han, Gang, Almhanna, Khaldoun, Kim, Richard, Valone, Tiffany, Jump, Helen, Sullivan, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Amyloid Precursor Protein Secretases - antagonists & inhibitors Antineoplastic Agents - therapeutic use Benzazepines - administration & dosage Benzazepines - therapeutic use Biological and medical sciences Colorectal cancer Colorectal Neoplasms - drug therapy Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Disease-Free Survival Female Gamma-secretase inhibitor Hematology, Oncology and Palliative Medicine Humans Male Medical sciences Middle Aged Notch pathway inhibitor Pharmacology. Drug treatments Phase II study Retreatment Tumors
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