Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression

Bovine Neonatal Pancytopenia (BNP), a fatal bleeding syndrome of neonatal calves, is caused by maternal alloantibodies absorbed from colostrum and is characterized by lymphocytopenia, thrombocytopenia and bone marrow hypoplasia. An inactivated viral vaccine is the likely source of alloantigens induc...

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Veröffentlicht in:	Scientific reports 2015-08, Vol.5 (1), p.12748-12748, Article 12748
Hauptverfasser:	Benedictus, Lindert, Luteijn, Rutger D., Otten, Henny, Jan Lebbink, Robert, van Kooten, Peter J. S., Wiertz, Emmanuel J. H. J., Rutten, Victor P. M. G., Koets, Ad P.
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/19 42/109 42/41 49/23 49/31 692/420/2780/2152/2153/1291 692/700/565/2194 82/29 82/58 Alloantibodies Alloantigens Animals Antibodies Antibody Specificity Bleeding Bone marrow Cattle Cattle Diseases - immunology Cell Line Colostrum Complement system Female Histocompatibility Antigens Class I - immunology Histocompatibility Antigens Class I - metabolism Humanities and Social Sciences Humans Hypoplasia Integrin beta1 - immunology Integrin beta1 - metabolism Isoantibodies - immunology Lymphopenia Lysis Major histocompatibility complex multidisciplinary Neonates Pancytopenia Pancytopenia - immunology Pancytopenia - veterinary Pathogenicity Pathogens Pregnancy Science Thrombocytopenia Vaccines Viral Vaccines - adverse effects
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