Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment

Hypoxia, as a pervasive feature in the microenvironment of solid tumors, plays a significant role in cancer progression, metastasis, and ultimately clinical outcome. One key cellular consequence of hypoxic stress is the regulation of DNA repair pathways, which contributes to the genomic instability...

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Veröffentlicht in:	DNA repair 2015-08, Vol.32, p.180-189
Hauptverfasser:	Scanlon, Susan E., Glazer, Peter M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins - genetics Ataxia Telangiectasia Mutated Proteins - metabolism Cell Hypoxia DNA Breaks, Double-Stranded DNA damage response DNA Mismatch Repair DNA repair DNA, Neoplasm - chemistry DNA, Neoplasm - metabolism Gene Expression Regulation, Neoplastic Gene regulation Gene silencing Genetic instability Genomic Instability Humans Hypoxia Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Post-translational modifications Protein Processing, Post-Translational Replication stress Signal Transduction Tumor microenvironment Tumor Microenvironment - genetics
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