FGF and stress regulate CREB and ATF‐1 via a pathway involving p38 MAP kinase and MAPKAP kinase‐2

Fibroblast growth factor (FGF) activates a protein kinase cascade in SK‐N‐MC cells that regulates gene expression at a cyclic‐AMP response element (CRE) by stimulating the transcriptional activity of CREB. The activation of CREB is prevented by a dominant negative mutant of Ras and triggered via the...

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Veröffentlicht in:	The EMBO journal 1996-09, Vol.15 (17), p.4629-4642
Hauptverfasser:	Tan, Y., Rouse, J., Zhang, A., Cariati, S., Cohen, P., Comb, M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 1 Amino Acid Sequence Astrocytes - metabolism Cyclic AMP Response Element-Binding Protein - metabolism DNA-Binding Proteins Enzyme Activation Fibroblast Growth Factors - metabolism Molecular Sequence Data Oxidative Stress Phosphorylation Protein Kinases - metabolism ras Proteins - genetics ras Proteins - metabolism Tetradecanoylphorbol Acetate - pharmacology Transcription Factors - metabolism Transcription, Genetic Tumor Cells, Cultured Type C Phospholipases - metabolism
Online-Zugang:	Volltext
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