Intracerebral hemorrhage outcomes following selective blockade or stimulation of the PGE2 EP1 receptor

Inflammation following intracerebral hemorrhage (ICH) significantly contributes to secondary brain damage and poor outcomes. Prostaglandin E2 (PGE2) is known to modulate neuroinflammatory responses and is upregulated in response to brain injury as a result of changes in inducible cyclooxygenase 2 (C...

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Veröffentlicht in:	BMC neuroscience 2015-08, Vol.16 (1), p.48-48, Article 48
Hauptverfasser:	Leclerc, Jenna L, Ahmad, Abdullah S, Singh, Nilendra, Soshnik-Schierling, Luke, Greene, Ellis, Dang, Alex, Doré, Sylvain
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - drug effects Astrocytes - immunology Astrocytes - pathology Blood-Brain Barrier - drug effects Blood-Brain Barrier - immunology Blood-Brain Barrier - pathology Brain - drug effects Brain - immunology Brain - pathology Cerebral Hemorrhage - drug therapy Cerebral Hemorrhage - immunology Cerebral Hemorrhage - pathology Collagenases Complications and side effects COX-2 inhibitors Disease Models, Animal Gliosis - drug therapy Gliosis - immunology Gliosis - pathology Hydrazines - pharmacology Iron - metabolism Leukocytes - drug effects Leukocytes - immunology Leukocytes - pathology Male Mice, Inbred C57BL Microglia - drug effects Microglia - immunology Microglia - pathology Neuroimmunomodulation - drug effects Neuroimmunomodulation - physiology Neuroprotective Agents - pharmacology Oxazepines - pharmacology Prostaglandins E Receptors, Prostaglandin E, EP1 Subtype - agonists Receptors, Prostaglandin E, EP1 Subtype - antagonists & inhibitors Receptors, Prostaglandin E, EP1 Subtype - metabolism Recovery of Function - drug effects
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