VAMP-7 links granule exocytosis to actin reorganization during platelet activation

Platelet activation results in profound morphologic changes accompanied by release of granule contents. Recent evidence indicates that fusion of granules with the plasma membrane during activation provides auxiliary membrane to cover growing actin structures. Yet little is known about how membrane f...

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Veröffentlicht in:	Blood 2015-07, Vol.126 (5), p.651-660
Hauptverfasser:	Koseoglu, Secil, Peters, Christian G., Fitch-Tewfik, Jennifer L., Aisiku, Omozuanvbo, Danglot, Lydia, Galli, Thierry, Flaumenhaft, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - physiology Actin-Related Protein 2-3 Complex - blood Animals Blood Platelets - physiology Blood Platelets - ultrastructure Cytoplasmic Granules - physiology Exocytosis - physiology Guanine Nucleotide Exchange Factors - blood Hematology Human health and pathology Humans Life Sciences Mice Mice, Inbred C57BL Mice, Knockout P-Selectin - blood Platelet Activation - physiology Platelet Aggregation - physiology Platelets and Thrombopoiesis R-SNARE Proteins - blood R-SNARE Proteins - deficiency R-SNARE Proteins - genetics
Online-Zugang:	Volltext
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