Crystal Structure of Human DNA Methyltransferase 1

DNMT1 (DNA methyltransferase 1) is responsible for propagating the DNA methylation patterns during DNA replication. DNMT1 contains, in addition to a C-terminal methyltransferase domain, a large N-terminal regulatory region that is composed of an RFTS (replication foci targeting sequence) domain, a C...

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Veröffentlicht in:	Journal of molecular biology 2015-07, Vol.427 (15), p.2520-2531
Hauptverfasser:	Zhang, Zhi-Min, Liu, Shuo, Lin, Krystal, Luo, Youfu, Perry, John Jefferson, Wang, Yinsheng, Song, Jikui
Format:	Artikel
Sprache:	eng
Schlagworte:	allosteric regulation Amino Acid Sequence autoinhibition Catalytic Domain - genetics crystal structure Crystallography, X-Ray DNA DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - chemistry DNA (Cytosine-5-)-Methyltransferases - genetics DNA (Cytosine-5-)-Methyltransferases - metabolism DNA methylation DNA replication DNA-binding proteins DNMT1 enzyme activity enzyme inhibition epigenetics functional diversity Homeostasis Humans methyltransferases mice Models, Molecular Mutation protein binding Protein Binding - genetics Protein Structure, Tertiary zinc finger motif Zinc Fingers - genetics
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