Molecular Mechanism for Hypertensive Renal Disease: Differential Regulation of Chromogranin A Expression at 3'-Untranslated Region Polymorphism C+87T by MicroRNA-107

Chromogranin A (CHGA) is coreleased with catecholamines from secretory vesicles in adrenal medulla and sympathetic axons. Genetic variation in the CHGA 3'-region has been associated with autonomic control of circulation, hypertension, and hypertensive nephropathy, and the CHGA 3'-untransla...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2015-08, Vol.26 (8), p.1816-1825
Hauptverfasser:	Zhang, Kuixing, Mir, Saiful A, Hightower, C Makena, Miramontes-Gonzalez, Jose Pablo, Maihofer, Adam X, Chen, Yuqing, Mahata, Sushil K, Nievergelt, Caroline M, Schork, Nicholas J, Freedman, Barry I, Vaingankar, Sucheta M, O'Connor, Daniel T
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions Alleles Animals Basic Research Blood Pressure Chromogranin A - genetics Chromogranin A - metabolism Glomerular Filtration Rate HEK293 Cells Humans Hypertension, Renal - genetics Hypertension, Renal - metabolism Luciferases Male Mice Mice, Transgenic MicroRNAs - genetics PC12 Cells Polymorphism, Genetic Rats
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