Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments

Summary Among the common complication of cirrhosis portal hypertension witnessed a major improvement of prognosis during the past decades. Principally due to the introduction of rational treatments based on new pathophysiological paradigms (concepts of thought) developed in the 1980s. The best examp...

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Veröffentlicht in:	Journal of hepatology 2015-04, Vol.62 (1), p.S121-S130
Hauptverfasser:	Bosch, Jaume, Groszmann, Roberto J, Shah, Vijay H
Format:	Artikel
Sprache:	eng
Schlagworte:	Endothelial dysfunction Gastroenterology and Hepatology Hepatic Artery - physiopathology Hepatic stellate cells Humans Hyperdynamic syndrome Hypertension, Portal - drug therapy Hypertension, Portal - physiopathology Liver Circulation Liver sinusoidal endothelial cells Neovascularization, Physiologic Portal pressure Splanchnic Circulation Splanchnic vasodilation
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