Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion

Degeneration of midbrain dopaminergic (DA) neurons is a key pathological event of Parkinson’s disease (PD). Limited adult dopaminergic neurogenesis has led to novel therapeutic strategies such as transplantation of dopaminergic precursors (DPs). However, this strategy is currently restrained by a la...

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Veröffentlicht in:	Scientific reports 2015-07, Vol.5 (1), p.12622-12622, Article 12622
Hauptverfasser:	Tian, Changhai, Li, Yuju, Huang, Yunlong, Wang, Yongxiang, Chen, Dapeng, Liu, Jinxu, Deng, Xiaobei, Sun, Lijun, Anderson, Kristi, Qi, Xinrui, Li, Yulong, Lee Mosley, R., Chen, Xiangmei, Huang, Jian, Zheng, Jialin C.
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/100 13/106 13/109 13/51 14 14/19 38 631/378/368/2430 631/532/2182 631/532/2435 692/699/375/1718 Action Potentials - drug effects Animals Cell Differentiation Cell Lineage Cell Proliferation - drug effects Cells, Cultured Dopamine receptors Dopaminergic Neurons - cytology Dopaminergic Neurons - metabolism Doxorubicin - toxicity Ectopic expression Fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Hepatocyte Nuclear Factor 3-beta - genetics Hepatocyte Nuclear Factor 3-beta - metabolism Humanities and Social Sciences Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - transplantation LIM-Homeodomain Proteins - genetics LIM-Homeodomain Proteins - metabolism Male Mesencephalon Mice Mice, Inbred C57BL Mice, Transgenic Motor task performance Movement disorders MPTP MPTP Poisoning - therapy multidisciplinary Neostriatum Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nestin - genetics Nestin - metabolism Neural stem cells Neural Stem Cells - cytology Neural Stem Cells - metabolism Neurodegeneration Neurodegenerative diseases Neurogenesis Otx Transcription Factors - genetics Otx Transcription Factors - metabolism Otx2 protein Parkinson's disease Patch-Clamp Techniques POU Domain Factors - genetics POU Domain Factors - metabolism Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Real-Time Polymerase Chain Reaction Rodents Science Serine Endopeptidases - genetics Serine Endopeptidases - metabolism SOXB1 Transcription Factors - genetics SOXB1 Transcription Factors - metabolism Transcription Factors - genetics Transcription Factors - metabolism Transplantation
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