A Synthetic Niche for Nephron Progenitor Cells

FGF, BMP, and WNT balance embryonic nephron progenitor cell (NPC) renewal and differentiation. By modulating these pathways, we have created an in vitro niche in which NPCs from embryonic kidneys or derived from human embryonic stem cells can be propagated. NPC cultures expanded up to one billion-fo...

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Veröffentlicht in:	Developmental cell 2015-07, Vol.34 (2), p.229-241
Hauptverfasser:	Brown, Aaron C., Muthukrishnan, Sree Deepthi, Oxburgh, Leif
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Morphogenetic Proteins - metabolism Cell Differentiation Cell Proliferation Cells, Cultured Embryonic Stem Cells - cytology Enzyme Activation Fibroblast Growth Factors - metabolism Homeodomain Proteins - biosynthesis Homeodomain Proteins - genetics Mice Mice, Inbred ICR Mice, Transgenic Nephrons - cytology Nephrons - embryology Nuclear Proteins - biosynthesis Nuclear Proteins - genetics Organogenesis Pyrazoles - pharmacology Pyrimidines - pharmacology Smad1 Protein - antagonists & inhibitors Smad1 Protein - metabolism Smad5 Protein - antagonists & inhibitors Smad5 Protein - metabolism Trans-Activators - biosynthesis Trans-Activators - genetics Transcription Factors - biosynthesis Transcription Factors - genetics Wnt Proteins - metabolism
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