Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study
Background Case series suggest that long-term use of proton pump inhibitors (PPIs) is associated with hypomagnesemia, but the current literature lacks systematically collected data. Our aim was to examine whether hypomagnesemia at the time of hospital admission is associated with out-of-hospital use...
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| Veröffentlicht in: | American journal of kidney diseases 2013-10, Vol.62 (4), p.730-737 |
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| creator | Koulouridis, Ioannis, MD, MS Alfayez, Mansour, MD Tighiouart, Hocine, MS Madias, Nicolaos E., MD Kent, David M., MD, MSc Paulus, Jessica K., ScD Jaber, Bertrand L., MD, MS |
| description | Background Case series suggest that long-term use of proton pump inhibitors (PPIs) is associated with hypomagnesemia, but the current literature lacks systematically collected data. Our aim was to examine whether hypomagnesemia at the time of hospital admission is associated with out-of-hospital use of PPIs. Study Design Nested case-control study matched for age and sex. Setting & Participants Data were collected retrospectively from a tertiary acute-care facility. Eligible cases consisted of 402 adults with hypomagnesemia (serum magnesium |
| doi_str_mv | 10.1053/j.ajkd.2013.02.373 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4518855</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0272638613006008</els_id><sourcerecordid>1435843759</sourcerecordid><originalsourceid>FETCH-LOGICAL-c606t-c7a057cebbd5ce2c1824c7a1914683897f971d1cf89ba7cfc44dc0c0ef968fc93</originalsourceid><addsrcrecordid>eNp9Uk1r3DAQNaWl2ab9Az0UXQq92NWHLdmlBJalyQZCE0hzFrI0TrSxpY1kB_bfV2a3249DTwPSezPvzZsse09wQXDFPm8KtXk0BcWEFZgWTLAX2YJUlOW8ZvXLbIGpoDlnNT_J3sS4wRg3jPPX2QlNpaxKscji9TTmvsvXPm7tqHp0FwH5Dt0EP3qHbqZhiy7dg23t6ENEyhm03m39oO4dRBisQmpER_LSDDZG690XtETfIY5g0EpFyFfejcH36HaczO5t9qpTfYR3h3qa3Z1_-7Fa51fXF5er5VWuOeZjroXCldDQtqbSQDWpaZneSEPK2V8jukYQQ3RXN60SutNlaTTWGLqG151u2Gl2tu-7ndoBjIakQfVyG-ygwk56ZeXfP84-yHv_LMuK1HVVpQafDg2Cf5qSHZnsaeh75cBPUZKSVXXJRDXPonuoDj7GAN1xDMFyTktu5JyWnNOSmMqUViJ9-FPgkfIrngT4eACoqFXfBeW0jb9xQrAGc55wX_c4SOt8thBk1BacBmMD6FEab_-v4-wfuu6ts2niI-wgbvwUXApKEhmpxPJ2vqv5rAjDmGNcs59aJ8ox</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1435843759</pqid></control><display><type>article</type><title>Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Koulouridis, Ioannis, MD, MS ; Alfayez, Mansour, MD ; Tighiouart, Hocine, MS ; Madias, Nicolaos E., MD ; Kent, David M., MD, MSc ; Paulus, Jessica K., ScD ; Jaber, Bertrand L., MD, MS</creator><creatorcontrib>Koulouridis, Ioannis, MD, MS ; Alfayez, Mansour, MD ; Tighiouart, Hocine, MS ; Madias, Nicolaos E., MD ; Kent, David M., MD, MSc ; Paulus, Jessica K., ScD ; Jaber, Bertrand L., MD, MS</creatorcontrib><description>Background Case series suggest that long-term use of proton pump inhibitors (PPIs) is associated with hypomagnesemia, but the current literature lacks systematically collected data. Our aim was to examine whether hypomagnesemia at the time of hospital admission is associated with out-of-hospital use of PPIs. Study Design Nested case-control study matched for age and sex. Setting & Participants Data were collected retrospectively from a tertiary acute-care facility. Eligible cases consisted of 402 adults with hypomagnesemia (serum magnesium <1.4 mEq/L) at the time of hospital admission to medical services, age- and sex-matched with 402 control individuals with normal serum magnesium levels (1.4-2.0 mEq/L). Predictor Out-of-hospital PPI use was identified in the hospital record. An omeprazole equivalent dose was calculated when possible. Covariates included the Charlson-Deyo comorbidity index, diabetes, diuretic use, estimated glomerular filtration rate, and gastroesophageal reflux. Outcome Multivariable conditional logistic regression analyses were used to examine the association of PPI use with hypomagnesemia at the time of hospital admission. Results PPI use was not associated with hypomagnesemia (adjusted OR, 0.82; 95% CI, 0.61-1.11). Neither PPI type nor omeprazole equivalent daily dose was associated with hypomagnesemia. Sensitivity analyses of PPI use restricted to patients with esophageal disorders (adjusted OR, 1.00; 95% CI, 0.69-1.45), severe hypomagnesemia (magnesium, ≤1.0 mEq/L; adjusted OR, 0.78; 95% CI, 0.13-4.61), or estimated glomerular filtration rate ≥60 mL/min/1.73 m2 (adjusted OR, 0.84; 95% CI, 0.53-1.34) were unrevealing. Limitations Exposure misclassification; hospitalized patients on medical services may not be representative of a broader ambulatory-based population. Conclusions In a hospital-based adult population, out-of-hospital PPI use is not associated with hypomagnesemia at the time of hospital admission to medical services. In light of these inconclusive results, prospective cohort studies are needed to address this rare potential medication-related adverse effect.</description><identifier>ISSN: 0272-6386</identifier><identifier>EISSN: 1523-6838</identifier><identifier>DOI: 10.1053/j.ajkd.2013.02.373</identifier><identifier>PMID: 23664547</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Case-Control Studies ; electrolyte disorders ; Female ; Humans ; Hypercalciuria - epidemiology ; Hypomagnesemia ; Male ; Medical sciences ; Metabolic diseases ; Metals (hemochromatosis...) ; Nephrocalcinosis - epidemiology ; Nephrology ; Nephrology. Urinary tract diseases ; Other metabolic disorders ; Patient Admission ; Prospective Studies ; proton pump inhibitors (PPIs) ; Proton Pump Inhibitors - therapeutic use ; Renal Tubular Transport, Inborn Errors - epidemiology ; Retrospective Studies</subject><ispartof>American journal of kidney diseases, 2013-10, Vol.62 (4), p.730-737</ispartof><rights>National Kidney Foundation, Inc.</rights><rights>2013 National Kidney Foundation, Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c606t-c7a057cebbd5ce2c1824c7a1914683897f971d1cf89ba7cfc44dc0c0ef968fc93</citedby><cites>FETCH-LOGICAL-c606t-c7a057cebbd5ce2c1824c7a1914683897f971d1cf89ba7cfc44dc0c0ef968fc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/j.ajkd.2013.02.373$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27739066$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23664547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Koulouridis, Ioannis, MD, MS</creatorcontrib><creatorcontrib>Alfayez, Mansour, MD</creatorcontrib><creatorcontrib>Tighiouart, Hocine, MS</creatorcontrib><creatorcontrib>Madias, Nicolaos E., MD</creatorcontrib><creatorcontrib>Kent, David M., MD, MSc</creatorcontrib><creatorcontrib>Paulus, Jessica K., ScD</creatorcontrib><creatorcontrib>Jaber, Bertrand L., MD, MS</creatorcontrib><title>Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Background Case series suggest that long-term use of proton pump inhibitors (PPIs) is associated with hypomagnesemia, but the current literature lacks systematically collected data. Our aim was to examine whether hypomagnesemia at the time of hospital admission is associated with out-of-hospital use of PPIs. Study Design Nested case-control study matched for age and sex. Setting & Participants Data were collected retrospectively from a tertiary acute-care facility. Eligible cases consisted of 402 adults with hypomagnesemia (serum magnesium <1.4 mEq/L) at the time of hospital admission to medical services, age- and sex-matched with 402 control individuals with normal serum magnesium levels (1.4-2.0 mEq/L). Predictor Out-of-hospital PPI use was identified in the hospital record. An omeprazole equivalent dose was calculated when possible. Covariates included the Charlson-Deyo comorbidity index, diabetes, diuretic use, estimated glomerular filtration rate, and gastroesophageal reflux. Outcome Multivariable conditional logistic regression analyses were used to examine the association of PPI use with hypomagnesemia at the time of hospital admission. Results PPI use was not associated with hypomagnesemia (adjusted OR, 0.82; 95% CI, 0.61-1.11). Neither PPI type nor omeprazole equivalent daily dose was associated with hypomagnesemia. Sensitivity analyses of PPI use restricted to patients with esophageal disorders (adjusted OR, 1.00; 95% CI, 0.69-1.45), severe hypomagnesemia (magnesium, ≤1.0 mEq/L; adjusted OR, 0.78; 95% CI, 0.13-4.61), or estimated glomerular filtration rate ≥60 mL/min/1.73 m2 (adjusted OR, 0.84; 95% CI, 0.53-1.34) were unrevealing. Limitations Exposure misclassification; hospitalized patients on medical services may not be representative of a broader ambulatory-based population. Conclusions In a hospital-based adult population, out-of-hospital PPI use is not associated with hypomagnesemia at the time of hospital admission to medical services. In light of these inconclusive results, prospective cohort studies are needed to address this rare potential medication-related adverse effect.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>electrolyte disorders</subject><subject>Female</subject><subject>Humans</subject><subject>Hypercalciuria - epidemiology</subject><subject>Hypomagnesemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Metals (hemochromatosis...)</subject><subject>Nephrocalcinosis - epidemiology</subject><subject>Nephrology</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Other metabolic disorders</subject><subject>Patient Admission</subject><subject>Prospective Studies</subject><subject>proton pump inhibitors (PPIs)</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Renal Tubular Transport, Inborn Errors - epidemiology</subject><subject>Retrospective Studies</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk1r3DAQNaWl2ab9Az0UXQq92NWHLdmlBJalyQZCE0hzFrI0TrSxpY1kB_bfV2a3249DTwPSezPvzZsse09wQXDFPm8KtXk0BcWEFZgWTLAX2YJUlOW8ZvXLbIGpoDlnNT_J3sS4wRg3jPPX2QlNpaxKscji9TTmvsvXPm7tqHp0FwH5Dt0EP3qHbqZhiy7dg23t6ENEyhm03m39oO4dRBisQmpER_LSDDZG690XtETfIY5g0EpFyFfejcH36HaczO5t9qpTfYR3h3qa3Z1_-7Fa51fXF5er5VWuOeZjroXCldDQtqbSQDWpaZneSEPK2V8jukYQQ3RXN60SutNlaTTWGLqG151u2Gl2tu-7ndoBjIakQfVyG-ygwk56ZeXfP84-yHv_LMuK1HVVpQafDg2Cf5qSHZnsaeh75cBPUZKSVXXJRDXPonuoDj7GAN1xDMFyTktu5JyWnNOSmMqUViJ9-FPgkfIrngT4eACoqFXfBeW0jb9xQrAGc55wX_c4SOt8thBk1BacBmMD6FEab_-v4-wfuu6ts2niI-wgbvwUXApKEhmpxPJ2vqv5rAjDmGNcs59aJ8ox</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Koulouridis, Ioannis, MD, MS</creator><creator>Alfayez, Mansour, MD</creator><creator>Tighiouart, Hocine, MS</creator><creator>Madias, Nicolaos E., MD</creator><creator>Kent, David M., MD, MSc</creator><creator>Paulus, Jessica K., ScD</creator><creator>Jaber, Bertrand L., MD, MS</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20131001</creationdate><title>Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study</title><author>Koulouridis, Ioannis, MD, MS ; Alfayez, Mansour, MD ; Tighiouart, Hocine, MS ; Madias, Nicolaos E., MD ; Kent, David M., MD, MSc ; Paulus, Jessica K., ScD ; Jaber, Bertrand L., MD, MS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c606t-c7a057cebbd5ce2c1824c7a1914683897f971d1cf89ba7cfc44dc0c0ef968fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>electrolyte disorders</topic><topic>Female</topic><topic>Humans</topic><topic>Hypercalciuria - epidemiology</topic><topic>Hypomagnesemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Metals (hemochromatosis...)</topic><topic>Nephrocalcinosis - epidemiology</topic><topic>Nephrology</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Other metabolic disorders</topic><topic>Patient Admission</topic><topic>Prospective Studies</topic><topic>proton pump inhibitors (PPIs)</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Renal Tubular Transport, Inborn Errors - epidemiology</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koulouridis, Ioannis, MD, MS</creatorcontrib><creatorcontrib>Alfayez, Mansour, MD</creatorcontrib><creatorcontrib>Tighiouart, Hocine, MS</creatorcontrib><creatorcontrib>Madias, Nicolaos E., MD</creatorcontrib><creatorcontrib>Kent, David M., MD, MSc</creatorcontrib><creatorcontrib>Paulus, Jessica K., ScD</creatorcontrib><creatorcontrib>Jaber, Bertrand L., MD, MS</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koulouridis, Ioannis, MD, MS</au><au>Alfayez, Mansour, MD</au><au>Tighiouart, Hocine, MS</au><au>Madias, Nicolaos E., MD</au><au>Kent, David M., MD, MSc</au><au>Paulus, Jessica K., ScD</au><au>Jaber, Bertrand L., MD, MS</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>62</volume><issue>4</issue><spage>730</spage><epage>737</epage><pages>730-737</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>Background Case series suggest that long-term use of proton pump inhibitors (PPIs) is associated with hypomagnesemia, but the current literature lacks systematically collected data. Our aim was to examine whether hypomagnesemia at the time of hospital admission is associated with out-of-hospital use of PPIs. Study Design Nested case-control study matched for age and sex. Setting & Participants Data were collected retrospectively from a tertiary acute-care facility. Eligible cases consisted of 402 adults with hypomagnesemia (serum magnesium <1.4 mEq/L) at the time of hospital admission to medical services, age- and sex-matched with 402 control individuals with normal serum magnesium levels (1.4-2.0 mEq/L). Predictor Out-of-hospital PPI use was identified in the hospital record. An omeprazole equivalent dose was calculated when possible. Covariates included the Charlson-Deyo comorbidity index, diabetes, diuretic use, estimated glomerular filtration rate, and gastroesophageal reflux. Outcome Multivariable conditional logistic regression analyses were used to examine the association of PPI use with hypomagnesemia at the time of hospital admission. Results PPI use was not associated with hypomagnesemia (adjusted OR, 0.82; 95% CI, 0.61-1.11). Neither PPI type nor omeprazole equivalent daily dose was associated with hypomagnesemia. Sensitivity analyses of PPI use restricted to patients with esophageal disorders (adjusted OR, 1.00; 95% CI, 0.69-1.45), severe hypomagnesemia (magnesium, ≤1.0 mEq/L; adjusted OR, 0.78; 95% CI, 0.13-4.61), or estimated glomerular filtration rate ≥60 mL/min/1.73 m2 (adjusted OR, 0.84; 95% CI, 0.53-1.34) were unrevealing. Limitations Exposure misclassification; hospitalized patients on medical services may not be representative of a broader ambulatory-based population. Conclusions In a hospital-based adult population, out-of-hospital PPI use is not associated with hypomagnesemia at the time of hospital admission to medical services. In light of these inconclusive results, prospective cohort studies are needed to address this rare potential medication-related adverse effect.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>23664547</pmid><doi>10.1053/j.ajkd.2013.02.373</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of kidney diseases, 2013-10, Vol.62 (4), p.730-737 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Aged Biological and medical sciences Case-Control Studies electrolyte disorders Female Humans Hypercalciuria - epidemiology Hypomagnesemia Male Medical sciences Metabolic diseases Metals (hemochromatosis...) Nephrocalcinosis - epidemiology Nephrology Nephrology. Urinary tract diseases Other metabolic disorders Patient Admission Prospective Studies proton pump inhibitors (PPIs) Proton Pump Inhibitors - therapeutic use Renal Tubular Transport, Inborn Errors - epidemiology Retrospective Studies |
| title | Out-of-Hospital Use of Proton Pump Inhibitors and Hypomagnesemia at Hospital Admission: A Nested Case-Control Study |
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