The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys
Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson’s disease (PD) patients significantly...
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| Veröffentlicht in: | Scientific reports 2015-07, Vol.5 (1), p.12178-12178, Article 12178 |
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| creator | Li, Hao Lei, Xiaoguang Yan, Ting Li, Hongwei Huang, Baihui Li, Ling Xu, Liqi Liu, Li Chen, Nanhui Lü, Longbao Ma, Yuanye Xu, Lin Li, Jiali Wang, Zhengbo Zhang, Baorong Hu, Xintian |
| description | Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson’s disease (PD) patients significantly improved their motor function. However, few studies have been focused on the optimization of parameters which contributed significantly to the treatment effects of tDCS and exploration of the underline neuronal mechanisms. Here, we used different stimulation parameters of anodal tDCS on M1 for the treatment of aged advanced PD monkeys induced with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) administration and then analyzed the temporary and accumulated effects of tDCS treatment. The results indicated anodal tDCS on M1 very significantly improved motor ability temporarily; importantly, the treatment effects of anodal tDCS on M1 were quantitatively correlated to the accumulated stimulation instead of the stimuli intensity or duration respectively. In addition, c-fos staining showed tDCS treatment effects activated the neurons both in M1 and substantia nigra (SN). Therefore, we propose that long time and continue anodal tDCS on M1 is a better strategy to improve the motor symptoms of PD than individual manipulation of stimuli intensity or duration. |
| doi_str_mv | 10.1038/srep12178 |
| format | Article |
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Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson’s disease (PD) patients significantly improved their motor function. However, few studies have been focused on the optimization of parameters which contributed significantly to the treatment effects of tDCS and exploration of the underline neuronal mechanisms. Here, we used different stimulation parameters of anodal tDCS on M1 for the treatment of aged advanced PD monkeys induced with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) administration and then analyzed the temporary and accumulated effects of tDCS treatment. The results indicated anodal tDCS on M1 very significantly improved motor ability temporarily; importantly, the treatment effects of anodal tDCS on M1 were quantitatively correlated to the accumulated stimulation instead of the stimuli intensity or duration respectively. In addition, c-fos staining showed tDCS treatment effects activated the neurons both in M1 and substantia nigra (SN). Therefore, we propose that long time and continue anodal tDCS on M1 is a better strategy to improve the motor symptoms of PD than individual manipulation of stimuli intensity or duration.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep12178</identifier><identifier>PMID: 26220760</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 631/378/1689/1718 ; 692/699/375/1718 ; Animals ; c-Fos protein ; Cortex (motor) ; Disease Models, Animal ; Electrical stimulation of the brain ; ESB ; Haplorhini ; Humanities and Social Sciences ; Motor task performance ; Movement disorders ; MPTP ; multidisciplinary ; Neurodegenerative diseases ; Neurological diseases ; Neurons - metabolism ; Parkinson Disease - diagnosis ; Parkinson Disease - metabolism ; Parkinson Disease - therapy ; Parkinson Disease, Secondary - chemically induced ; Parkinson Disease, Secondary - pathology ; Parkinson Disease, Secondary - therapy ; Parkinson's disease ; Proto-Oncogene Proteins c-fos - metabolism ; Science ; Substantia nigra ; Substantia Nigra - metabolism ; Transcranial Direct Current Stimulation - methods ; Treatment Outcome ; Tyrosine 3-Monooxygenase - metabolism</subject><ispartof>Scientific reports, 2015-07, Vol.5 (1), p.12178-12178, Article 12178</ispartof><rights>The Author(s) 2015</rights><rights>Copyright Nature Publishing Group Jul 2015</rights><rights>Copyright © 2015, Macmillan Publishers Limited 2015 Macmillan Publishers Limited</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-f6ea8484492afa7c04ad267aea4a10f1be650330cf1fd41c1f51dd2a98299f213</citedby><cites>FETCH-LOGICAL-c438t-f6ea8484492afa7c04ad267aea4a10f1be650330cf1fd41c1f51dd2a98299f213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518219/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4518219/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26220760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Lei, Xiaoguang</creatorcontrib><creatorcontrib>Yan, Ting</creatorcontrib><creatorcontrib>Li, Hongwei</creatorcontrib><creatorcontrib>Huang, Baihui</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Xu, Liqi</creatorcontrib><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Chen, Nanhui</creatorcontrib><creatorcontrib>Lü, Longbao</creatorcontrib><creatorcontrib>Ma, Yuanye</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Li, Jiali</creatorcontrib><creatorcontrib>Wang, Zhengbo</creatorcontrib><creatorcontrib>Zhang, Baorong</creatorcontrib><creatorcontrib>Hu, Xintian</creatorcontrib><title>The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson’s disease (PD) patients significantly improved their motor function. However, few studies have been focused on the optimization of parameters which contributed significantly to the treatment effects of tDCS and exploration of the underline neuronal mechanisms. Here, we used different stimulation parameters of anodal tDCS on M1 for the treatment of aged advanced PD monkeys induced with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) administration and then analyzed the temporary and accumulated effects of tDCS treatment. The results indicated anodal tDCS on M1 very significantly improved motor ability temporarily; importantly, the treatment effects of anodal tDCS on M1 were quantitatively correlated to the accumulated stimulation instead of the stimuli intensity or duration respectively. In addition, c-fos staining showed tDCS treatment effects activated the neurons both in M1 and substantia nigra (SN). Therefore, we propose that long time and continue anodal tDCS on M1 is a better strategy to improve the motor symptoms of PD than individual manipulation of stimuli intensity or duration.</description><subject>13</subject><subject>631/378/1689/1718</subject><subject>692/699/375/1718</subject><subject>Animals</subject><subject>c-Fos protein</subject><subject>Cortex (motor)</subject><subject>Disease Models, Animal</subject><subject>Electrical stimulation of the brain</subject><subject>ESB</subject><subject>Haplorhini</subject><subject>Humanities and Social Sciences</subject><subject>Motor task performance</subject><subject>Movement disorders</subject><subject>MPTP</subject><subject>multidisciplinary</subject><subject>Neurodegenerative diseases</subject><subject>Neurological diseases</subject><subject>Neurons - metabolism</subject><subject>Parkinson Disease - diagnosis</subject><subject>Parkinson Disease - metabolism</subject><subject>Parkinson Disease - therapy</subject><subject>Parkinson Disease, Secondary - chemically induced</subject><subject>Parkinson Disease, Secondary - pathology</subject><subject>Parkinson Disease, Secondary - therapy</subject><subject>Parkinson's disease</subject><subject>Proto-Oncogene Proteins c-fos - metabolism</subject><subject>Science</subject><subject>Substantia nigra</subject><subject>Substantia Nigra - metabolism</subject><subject>Transcranial Direct Current Stimulation - methods</subject><subject>Treatment Outcome</subject><subject>Tyrosine 3-Monooxygenase - metabolism</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkdFuFCEUhonR2GbthS9gSLxRk63AMDNwY2IaqyZN9KJek1Pm0NLOwApMk971AfoCvl6fRNZtN6sSAoTz8_HDT8hLzg45a9T7nHDFBe_VE7IvmGyXohHi6c56jxzkfMlqa4WWXD8ne6ITgvUd2yd3pxdIC06rmCDdUAgDBWvnaR6h4EDRObQl0-hoSRCyrYOHkQ4-1X1q55QwFJqL_3PCx0BdTLSsoQmhTOtqPQzDNQRbgd8hXfmQY7i__ZUrJiNkpFMMV3iTX5BnDsaMBw_zgvw4_nR69GV58u3z16OPJ0srG1WWrkNQUkmpBTjoLZMwiK4HBAmcOX6GXcuahlnH3SC55a7lwyBAK6G1E7xZkA8b7mo-m3Cw1WSC0aySn-onmAje_F0J_sKcx2sjW64E1xXw5gGQ4s8ZczGTzxbHEQLGORves2pArvuCvP5HehnnFOrzDFdat51Qqq-qtxuVTTHXRN3WDGdmHbPZxly1r3bdb5WPoVbBu40g11I4x7Rz5X-033DLtmc</recordid><startdate>20150729</startdate><enddate>20150729</enddate><creator>Li, Hao</creator><creator>Lei, Xiaoguang</creator><creator>Yan, Ting</creator><creator>Li, Hongwei</creator><creator>Huang, Baihui</creator><creator>Li, Ling</creator><creator>Xu, Liqi</creator><creator>Liu, Li</creator><creator>Chen, Nanhui</creator><creator>Lü, Longbao</creator><creator>Ma, Yuanye</creator><creator>Xu, Lin</creator><creator>Li, Jiali</creator><creator>Wang, Zhengbo</creator><creator>Zhang, Baorong</creator><creator>Hu, Xintian</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150729</creationdate><title>The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys</title><author>Li, Hao ; Lei, Xiaoguang ; Yan, Ting ; Li, Hongwei ; Huang, Baihui ; Li, Ling ; Xu, Liqi ; Liu, Li ; Chen, Nanhui ; Lü, Longbao ; Ma, Yuanye ; Xu, Lin ; Li, Jiali ; Wang, Zhengbo ; Zhang, Baorong ; Hu, Xintian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-f6ea8484492afa7c04ad267aea4a10f1be650330cf1fd41c1f51dd2a98299f213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>13</topic><topic>631/378/1689/1718</topic><topic>692/699/375/1718</topic><topic>Animals</topic><topic>c-Fos protein</topic><topic>Cortex (motor)</topic><topic>Disease Models, Animal</topic><topic>Electrical stimulation of the brain</topic><topic>ESB</topic><topic>Haplorhini</topic><topic>Humanities and Social Sciences</topic><topic>Motor task performance</topic><topic>Movement disorders</topic><topic>MPTP</topic><topic>multidisciplinary</topic><topic>Neurodegenerative diseases</topic><topic>Neurological diseases</topic><topic>Neurons - metabolism</topic><topic>Parkinson Disease - diagnosis</topic><topic>Parkinson Disease - metabolism</topic><topic>Parkinson Disease - therapy</topic><topic>Parkinson Disease, Secondary - chemically induced</topic><topic>Parkinson Disease, Secondary - pathology</topic><topic>Parkinson Disease, Secondary - therapy</topic><topic>Parkinson's disease</topic><topic>Proto-Oncogene Proteins c-fos - metabolism</topic><topic>Science</topic><topic>Substantia nigra</topic><topic>Substantia Nigra - metabolism</topic><topic>Transcranial Direct Current Stimulation - methods</topic><topic>Treatment Outcome</topic><topic>Tyrosine 3-Monooxygenase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Hao</creatorcontrib><creatorcontrib>Lei, Xiaoguang</creatorcontrib><creatorcontrib>Yan, Ting</creatorcontrib><creatorcontrib>Li, Hongwei</creatorcontrib><creatorcontrib>Huang, Baihui</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Xu, Liqi</creatorcontrib><creatorcontrib>Liu, Li</creatorcontrib><creatorcontrib>Chen, Nanhui</creatorcontrib><creatorcontrib>Lü, Longbao</creatorcontrib><creatorcontrib>Ma, Yuanye</creatorcontrib><creatorcontrib>Xu, Lin</creatorcontrib><creatorcontrib>Li, Jiali</creatorcontrib><creatorcontrib>Wang, Zhengbo</creatorcontrib><creatorcontrib>Zhang, Baorong</creatorcontrib><creatorcontrib>Hu, Xintian</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hao</au><au>Lei, Xiaoguang</au><au>Yan, Ting</au><au>Li, Hongwei</au><au>Huang, Baihui</au><au>Li, Ling</au><au>Xu, Liqi</au><au>Liu, Li</au><au>Chen, Nanhui</au><au>Lü, Longbao</au><au>Ma, Yuanye</au><au>Xu, Lin</au><au>Li, Jiali</au><au>Wang, Zhengbo</au><au>Zhang, Baorong</au><au>Hu, Xintian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2015-07-29</date><risdate>2015</risdate><volume>5</volume><issue>1</issue><spage>12178</spage><epage>12178</epage><pages>12178-12178</pages><artnum>12178</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson’s disease (PD) patients significantly improved their motor function. However, few studies have been focused on the optimization of parameters which contributed significantly to the treatment effects of tDCS and exploration of the underline neuronal mechanisms. Here, we used different stimulation parameters of anodal tDCS on M1 for the treatment of aged advanced PD monkeys induced with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) administration and then analyzed the temporary and accumulated effects of tDCS treatment. The results indicated anodal tDCS on M1 very significantly improved motor ability temporarily; importantly, the treatment effects of anodal tDCS on M1 were quantitatively correlated to the accumulated stimulation instead of the stimuli intensity or duration respectively. In addition, c-fos staining showed tDCS treatment effects activated the neurons both in M1 and substantia nigra (SN). Therefore, we propose that long time and continue anodal tDCS on M1 is a better strategy to improve the motor symptoms of PD than individual manipulation of stimuli intensity or duration.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26220760</pmid><doi>10.1038/srep12178</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 13 631/378/1689/1718 692/699/375/1718 Animals c-Fos protein Cortex (motor) Disease Models, Animal Electrical stimulation of the brain ESB Haplorhini Humanities and Social Sciences Motor task performance Movement disorders MPTP multidisciplinary Neurodegenerative diseases Neurological diseases Neurons - metabolism Parkinson Disease - diagnosis Parkinson Disease - metabolism Parkinson Disease - therapy Parkinson Disease, Secondary - chemically induced Parkinson Disease, Secondary - pathology Parkinson Disease, Secondary - therapy Parkinson's disease Proto-Oncogene Proteins c-fos - metabolism Science Substantia nigra Substantia Nigra - metabolism Transcranial Direct Current Stimulation - methods Treatment Outcome Tyrosine 3-Monooxygenase - metabolism |
| title | The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys |
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