Toll-Like Receptor 9 Inactivation Alleviated Atherosclerotic Progression and Inhibited Macrophage Polarized to M1 Phenotype in ApoE−/− Mice

Objective. Toll-like receptor 9 (TLR9) is involved in many inflammatory diseases, but its role in atherosclerosis remains controversial. This study aimed to investigate the role of TLR9 in atherosclerosis development and macrophage polarization. Methods. ApoE−/− mice were treated with vehicle or IRS...

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Veröffentlicht in:	Disease markers 2015-01, Vol.2015 (2015), p.1-9
Hauptverfasser:	Lin, Ling, Lin, Ye, Chen, Xiaoqing, Huang, Ziyang, Ouyang, Qiufang, Ma, Chunmei, Hu, Weiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apolipoproteins E - genetics Apolipoproteins E - metabolism Atherosclerosis - immunology Atherosclerosis - metabolism Atherosclerosis - pathology Cell Line Female Interferon Regulatory Factor-7 - genetics Interferon Regulatory Factor-7 - metabolism Macrophage Activation Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL NF-kappa B - genetics NF-kappa B - metabolism Phenotype Toll-Like Receptor 9 - antagonists & inhibitors Toll-Like Receptor 9 - metabolism
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