Direct Coupling of a Seven-Transmembrane-Span Receptor to a Gαi G-Protein Regulatory Motif Complex

Group II activator of G-protein signaling (AGS) proteins contain one or more G-protein regulatory motifs (GPR), which serve as docking sites for GαiGDP independent of Gβγ and stabilize the GDP-bound conformation of Gαi, acting as guanine nucleotide dissociation inhibitors. The GαGPR interaction is r...

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Veröffentlicht in:	Molecular pharmacology 2015-08, Vol.88 (2), p.231-237
Hauptverfasser:	Robichaux, William G., Oner, Sukru S., Lanier, Stephen M., Blumer, Joe B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Accelerated Communications Animals Bioluminescence Resonance Energy Transfer Techniques - methods GTP-Binding Protein alpha Subunit, Gi2 - chemistry GTP-Binding Protein alpha Subunit, Gi2 - genetics GTP-Binding Protein alpha Subunit, Gi2 - metabolism GTP-Binding Protein alpha Subunits, Gi-Go - chemistry GTP-Binding Protein alpha Subunits, Gi-Go - genetics GTP-Binding Protein alpha Subunits, Gi-Go - metabolism GTP-Binding Proteins - chemistry GTP-Binding Proteins - metabolism HEK293 Cells Humans Models, Molecular Molecular Docking Simulation Mutation Pertussis Toxin - pharmacology Protein Conformation - drug effects Rats Receptors, G-Protein-Coupled - chemistry Receptors, G-Protein-Coupled - metabolism
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